Results 111 to 120 of about 9,212,440 (297)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Spatiotemporal occupancy patterns of chronic wasting disease

Frontiers in Veterinary Science
IntroductionChronic wasting disease (CWD) among cervids in Kansas has seen a consistent rise over the years, both in terms of the number of infections and its geographical spread.
Amy J. Davis, Shane Hesting, Levi Jaster, Joseph E. Mosley, Akila Raghavan, Ram K. Raghavan, Ram K. Raghavan   +6 more
doaj   +1 more source

Huntington's Disease Association of Ireland [explanatory report].

, 1998
Huntington's Disease Association of Ireland: (HDAI) provides consultation, information and individualised support to those diagnosed with Huntington's disease (HD), their families and their health care team.
Hunington's Disease Association of Ireland.
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Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Reportable communicable disease summary (Online)

, 2000
Provides tables, charts, and maps showing incidence of various reported communicable diseases in Oregon by ten-year period, by onset month of current year, by age and sex, and by map showing incidence range by county.-1999This archived document is ...

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Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Prescription patterns of traditional Chinese medications and potential consequences in patients with new-onset cardiac or vascular-related diseases: a nationwide cohort study

BMC Complementary Medicine and Therapies
Background The patterns of Chinese medicine prescriptions, corresponding diagnoses, co-morbidities, and Western medication (WM) use among patients with cardiac or vascular-related diseases are uncertain.
Sheng-Shing Lin, Hsin-Hui Tsai, Daniel Hsiang-Te Tsai, Chiu-Lin Tsai, Nanae Itokazu, Jaung-Geng Lin, Edward Chia-Cheng Lai, Hsiang-Wen Lin, Yu-Chang Hou   +8 more
doaj   +1 more source

Waterborne disease outbreak investigation toolkit [PDF]

The purpose of this toolkit is to assist state and local health departments in conducting waterborne disease outbreak investigations.Disease outbreaks that involve transmission through water can present unique challenges due to the numerous ways that ...

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