Results 91 to 100 of about 9,212,440 (297)

Clinical presentation of Crohn's disease. Association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery [PDF]

, 2005
Background/Aims: Recent molecular data suggest that genetic factors may underlie the disease heterogeneity observed in Crohn's disease (CD). It was also suggested that familial inflammatory bowel disease (IBD) is a homogenous subgroup, phenotypically ...
Gasztonyi, Beáta, Kovács, Attila, Figler, Mária, Szalay, Ferenc, Cseh, J., Mikó, Éva, Horváth, Gábor, Szekeres Barthó, J., Papp, János, Lakatos, Péter László, Molnár, Tamás, Kovács, Ágota, Lakatos, Péter, Hunyady, Béla, Tulassay, Zsolt, Kisbenedek, A. G., Lakatos, László   +16 more
core   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Association Between Multimorbid Disease Patterns and Pain Outcomes Among a Complex Chronic Care Population in Canada

Journal of Pain Research, 2020
Meaghan Ferguson,1 Anton Svendrovski,2 Joel Katz1 1Department of Psychology, Faculty of Health, York University, Toronto, Ontario, Canada; 2Department of Psychology, UZIK Consulting Inc, Toronto, Ontario, CanadaCorrespondence: Meaghan Ferguson; Joel ...
Ferguson M, Svendrovski A, Katz J
doaj  

Histopathologic pattern of thyroid disease

East African Medical Journal, 2004
Diseases of the thyroid are manifested by alteration in hormone secretion, enlargement of the thyroid gland (goiter), or both. The principal diseases of the thyroid gland are goiter (diffuse or nodular), hypo or hyperthyroidism, thyroiditis and neoplasms. The incidence and prevalence of these thyroid diseases in a given community are variable depending
Tsegaye, B, Ergete, W
openaire   +4 more sources

Polymorphism and XDuce-style patterns

, 2008
We present an extension of XDuce, a programming language dedicated to the processing of XML documents, with polymorphism and abstract types, two crucial features for programming in the large.
Xduce-style Patterns, Jerome Vouillon
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Assessment of dietary patterns in celiac disease patients using factor analysis method and their relationship with dietary intakes and body mass index

BMC Nutrition
Background/Objectives Celiac disease (CD) is a systemic and autoimmune enteropathy of the gastrointestinal tract with malabsorption characteristics. The only effective treatment for CD is adhere strictly to a gluten-free diet (GFD) throughout life.
Mehrnaz Morvaridi, Narges Sadeghi, Pezhman Alavinejad, Mehdi Sadeghian, Negin Tahvilian, Hossein Bavi Behbahani, Sara Ebrahimi, Farnaz Farsi   +7 more
doaj   +1 more source

Global co-occurrence patterns of cancer and cardiovascular disease: a comprehensive analysis based on the Global Burden of Disease Study 2021

Archives of Medical Science
Introduction Cardiovascular disease (CVD) and neoplasms are the two leading causes of death worldwide. Previous research has predominantly addressed these conditions separately or focused on specific regions.
Xiaohan Qiu, Ben Hu, Jiahan Ke, Jun Gu
doaj   +1 more source

Nosocomial Legionnaires’ Disease: Clinical and Radiographic Patterns

Canadian Journal of Infectious Diseases, 1992
From 1981 to 1991, 55 patients (33 males, 22 females, mean age 58.6 years) with nosocomial Legionnaires’ disease were studied. The mortality rate was 64%. One-half of the patients developed nosocomial Legionnaires’ disease within three weeks of admission.
Thomas J Marrie, David Haldane, Gregory Bezanson   +2 more
doaj   +1 more source