Results 81 to 90 of about 9,212,440 (297)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Nutrient patterns and mortality: results from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study

Nutrition Journal
Background The consumption of a healthy diet may play an important role in the prevention of noncommunicable diseases (NCDs). Although associations between nutrient patterns and cardiometabolic risk factors or NCDs have been examined, the associations ...
Akari Matsuura, Takeshi Watanabe, Yuka Torii, Kahori Kita, Taichi Unohara, Masashi Ishizu, Jun Otonari, Hiroaki Ikezaki, Megumi Hara, Yuichiro Nishida, Mako Nagayoshi, Kenji Wakai, Yasufumi Kato, Takashi Matsunaga, Yuriko N. Koyanagi, Isao Oze, Nobuaki Michihata, Yohko Nakamura, Chihaya Koriyama, Daisaku Nishimoto, Sadao Suzuki, Takahiro Otani, Naoyuki Takashima, Etsuko Ozaki, Kiyonori Kuriki, Naoko Miyagawa, Keiko Kondo, Takashi Tamura, Keitaro Matsuo, for the J.-MICC Study Group   +29 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Adherence to Dietary Patterns and Cardiovascular Disease Risk: A Cross-Sectional Study of Total Carotid Plaque Area in Argentina

Journal of Lipid and Atherosclerosis
Objective Assessing subclinical atherosclerosis (sAT) is crucial for preventing cardiovascular disease. The Mediterranean diet is considered the gold standard for cardiovascular protection, but cultural and economic barriers can hinder adherence to it ...
Mariana N. Carrillo, Matias Garribia, Luis Armando, Akinwunmi Oluwaseun Adeoye, Nestor H. Garcia, Sonia E. Muñoz   +5 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The pyroptosis mediated biomarker pattern: an emerging diagnostic approach for Parkinson’s disease

Cellular & Molecular Biology Letters
Background Parkinson’s disease (PD) affects 1% of people over 60, and long-term levodopa treatment can cause side effects. Early diagnosis is of great significance in slowing down the pathological process of PD.
Junhan Liang, Zhirong Wan, Cheng Qian, Madiha Rasheed, Changling Cao, Jingyan Sun, Xuezhe Wang, Zixuan Chen, Yulin Deng   +8 more
doaj   +1 more source

Liangfang Wenjing decoction regulates endoplasmic reticulum stress-mediated apoptosis to alleviate uterine microvascular injury in cold-stressed rats

Frontiers in Pharmacology
BackgroundCold exposure can induce microvascular damage, which in turn contributes to various gynecological disorders. Liangfang Wenjing Decoction (LFWJD), a classical botanical drug prescription, has long been used to treat gynecological diseases caused
Tianyuan Lv, Yue Hu, Xueyan Ma, Liqun Feng, Di Wang, Xiaodan Song, Sisi Xue, Shuai Lu, Xiumei Cheng, Xiumei Cheng, Xiumei Cheng   +10 more
doaj   +1 more source

Patterns Of Disease In Community Genral Hospitals

Journal of Nepal Medical Association, 2003
NA
Thomas W Simpson
doaj   +1 more source

Assessment of outcome in clinical trials in mild Alzheimer 19s disease: urgent time for a rethink? [PDF]

, 2013
Introduction: A major barrier for clinical trials in Alzheimer's disease is the lack of sensitive clinical endpoints for the early stages. Until recently, regulatory agencies have required demonstration of improvement in two disease domains, cognition ...
McGoldrick, S., Duffy, Fiona, McGoldrick, Susan, Reynish, Emma, Kelly, Fiona, Morrison, Y., Wilson, L., Bennett, Crispin, Wilson, J T Lindsay, Bennett, C., Morrison, Yvonne, Duffy, F., Reynish, E.   +12 more
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