Results 191 to 200 of about 9,212,440 (297)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Atrial Fibrillation in Geriatric Patients: A Cross-Sectional Analysis of Risk Factors and Disease Patterns. [PDF]

Cureus
Palaparthi EC, Titty NA, Bhuyar BK, Gudimalla A, Nandyala PSKR, Vivekanandan V, Kandimalla R.   +6 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The patterns of disease in Africa.

The Central African journal of medicine, 1971
openaire   +4 more sources

Capi-score: a quantitative algorithm for identifying disease patterns in nailfold videocapillaroscopy. [PDF]

Rheumatology (Oxford)
Gracia Tello BDC, Sáez Comet L, Lledó G, Freire Dapena M, Mesa MA, Martín-Cascón M, Guillén Del Castillo A, Martínez Robles E, Simeón-Aznar CP, Todolí Parra JA, Varela DC, Maldonado Vélez G, Marín Ballvé A, Aramburu Llorente J, Pérez Abad L, Ramos Ibáñez E.   +15 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Assessing health system and service delivery capacity in responding to changing disease patterns in the Philippines: an analysis using national health information system longitudinal data. [PDF]

Hum Resour Health
Feng Y, Tanghal RD, Laolao BI, Shi J, Bi Y, Wang J, Wang M, Jin Y, Liu Y, China-ASEAN Science, Technology Cooperation Center for Public Health.   +10 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Respiratory disease patterns in rural Western Uganda, 2019-2022. [PDF]

Front Pediatr
Weary TE, Tusiime P, Tuhaise S, Mandujano Reyes JF, Ross E, Gern JE, Goldberg TL.   +6 more
europepmc   +1 more source