Results 121 to 130 of about 12,637,526 (357)

Generic protease detection technology for monitoring periodontal disease

, 2011
Periodontal diseases are inflammatory conditions that affect the supporting tissues of teeth and can lead to destruction of the bone support and ultimately tooth loss if untreated.
Cook, Joseph P., Douglas, Ian, Krause, Steffi, Rawlinson, Andrew, Watkinson, Michael, Yang, Shoufeng, Zheng, Xinwei   +6 more
core   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Dietary inflammatory index is associated with metabolic dysfunction-associated fatty liver disease among United States adults

Frontiers in Nutrition
BackgroundMetabolic dysfunction-associated fatty liver disease (MAFLD) is presently the most prevalent chronic liver disorder globally that is closely linked to obesity, dyslipidemia metabolic syndrome, and type 2 diabetes mellitus (T2DM).
Jing Yan, Jing Yan, Jun Zhou, Yuanyuan Ding, Chuantao Tu   +4 more
doaj   +1 more source

Variants in the SNCA Locus Are Associated With the Progression of Parkinson's Disease

Frontiers in Aging Neuroscience, 2019
Background: Genetic factors have a well-known influence on Parkinson's disease (PD) susceptibility; however, no previous studies have investigated the influence of SNCA mutations on the natural history of PD using a prospective follow-up study.
Ningdi Luo, Yuanyuan Li, Mengyue Niu, Liche Zhou, Mengsha Yao, Lin Zhu, Guanyu Ye, Wenyan Kang, Wenyan Kang, Jun Liu, Jun Liu   +10 more
doaj   +1 more source

Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study [PDF]

, 2017
Spironolactone improves outcome in dogs with advanced myxomatous mitral valve disease (MMVD). Its efficacy in preclinical MMVD is unknown. The hypothesis was the administration of spironolactone to dogs with compensated MMVD demonstrating risk factors ...
Boswood, A, Elliott, J, Hezzell, M J, Lopez-Alvarez, J, Lotter, N S   +4 more
core   +3 more sources

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Early Detection of Disease Progression in Metastatic Cancers: Could CTCs Improve RECIST Criteria?

Biomedicines
Early detection of disease progression is a crucial issue in the management of cancer patients, especially in metastatic settings. Currently, treatment selection mostly relies on criteria based on radiologic evaluations (RECIST).
Valentina Magri, Luca Marino, Gianluigi De Renzi, Michela De Meo, Francesca Salvatori, Dorelsa Buccilli, Vincenzo Bianco, Daniele Santini, Chiara Nicolazzo, Paola Gazzaniga   +9 more
doaj   +1 more source

Toward Cultural Oncology: The Evolutionary Information Dynamics of Cancer [PDF]

, 2003
'Racial' disparities among cancers, particularly of the breast and prostate, are something of a mystery. For the US, in the face of slavery and its sequelae, centuries of interbreeding have greatly leavened genetic differences between 'Blacks' and ...
Wallace, Deborah, Wallace, Robert G., Wallace, Rodrick   +2 more
core   +2 more sources

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Insights into Disease Progression of Translational Preclinical Rat Model of Interstitial Pulmonary Fibrosis through Endpoint Analysis

Cells
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease characterized by the relentless deposition of extracellular matrix (ECM), causing lung distortions and dysfunction.
Anil H. Kadam, Jan E. Schnitzer
doaj   +1 more source