Results 141 to 150 of about 12,789,497 (387)

Temporal trends in colorectal cancer mortality rates (1999–2022) in the United States

Cancer Reports
Colorectal cancer (CRC) ranks as the third leading cause of cancer‐related deaths in the United States (U.S.). Our study aims to analyze CRC mortality patterns in the U.S., focusing on gender and age groups from 1999 to 2022.
Fariha Ilyas, Eiman Ahmed, Hassam Ali, Maheen Ilyas, Shiza Sarfraz, Mahnoor Khalid, Muhammad Khalaf, Prashant Reddy Mudireddy   +7 more
doaj   +1 more source

MMP-7 is a predictive biomarker of disease progression in patients with idiopathic pulmonary fibrosis

ERJ Open Research, 2017
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with poor prognosis, which is characterised by destruction of normal lung architecture and excessive deposition of lung extracellular matrix.
Y. Bauer, E. White, S. de Bernard, P. Cornelisse, I. Leconte, A. Morganti, S. Roux, O. Nayler   +7 more
semanticscholar   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Diabetic Kidney Disease: Disease Progression Driven by Positive Feedback Loops and Therapeutic Strategies Targeting Pathogenic Pathways

Diabetes, Metabolic Syndrome and Obesity
Gaozhi P Mo,1,* Yao Zhu,1,* Yue You,1 Hui Chen,1 Jiahao Zhang,1 Bunhav Ku,1 Haichuan Yu,1 Zhiyong Peng1,2 1Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China; 2Hubei Clinical ...
Mo GP, Zhu Y, You Y, Chen H, Zhang J, Ku B, Yu H, Peng Z   +7 more
doaj  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Surgery as deterrent to progression of coronary artery disease [PDF]

, 1975
Rose Marie Lee
openalex   +1 more source

Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression

PLoS Pathogens, 2017
Aspergillus fumigatus is responsible for a disproportionate number of invasive mycosis cases relative to other common filamentous fungi. While many fungal factors critical for infection establishment are known, genes essential for disease persistence and
S. Beattie, Kenneth M K Mark, A. Thammahong, L. Ries, S. Dhingra, A. Caffrey-Carr, Chao Cheng, C. Black, P. Bowyer, M. Bromley, Joshua J. Obar, G. Goldman, R. Cramer   +12 more
semanticscholar   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

Neuron, 2020
B. Bai, Xusheng Wang, Yuxin Li, Ping-Chung Chen, Kaiwen Yu, K. Dey, Jay M. Yarbro, Xian Han, Brianna M. Lutz, Shuquan Rao, Y. Jiao, Jeffrey M. Sifford, Jonghee Han, Minghui Wang, H. Tan, T. Shaw, Ji-Hoon Cho, Suiping Zhou, Hong Wang, Mingming Niu, Ariana Mancieri, Kaitlynn A. Messler, Xiaojun Sun, Zhiping Wu, V. Pagala, A. High, W. Bi, Hui Zhang, H. Chi, V. Haroutunian, Bin Zhang, T. Beach, Gang Yu, Junmin Peng   +33 more
semanticscholar   +1 more source