Results 141 to 150 of about 12,637,526 (357)

Diabetic Kidney Disease: Disease Progression Driven by Positive Feedback Loops and Therapeutic Strategies Targeting Pathogenic Pathways

Diabetes, Metabolic Syndrome and Obesity
Gaozhi P Mo,1,* Yao Zhu,1,* Yue You,1 Hui Chen,1 Jiahao Zhang,1 Bunhav Ku,1 Haichuan Yu,1 Zhiyong Peng1,2 1Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China; 2Hubei Clinical ...
Mo GP, Zhu Y, You Y, Chen H, Zhang J, Ku B, Yu H, Peng Z   +7 more
doaj  

Tailoring advanced breast cancer treatment after cyclin-dependent kinase 4/6 inhibitors progression - real-world data analysis

Frontiers in Oncology
BackgroundCyclin-dependent kinase 4/6 inhibitors (CDK4/6i) represent the gold standard of the hormone receptor positive human epidermal growth factor receptor 2 (HER-2) negative advanced breast cancer. However, optimal treatment after disease progression
Marcin Kubeczko, Anna Polakiewicz-Gilowska, Katarzyna Świderska, Aleksandra Leśniak, Marta Mianowska-Malec, Barbarba Łanoszka, Konstanty Chomik, Barbara Grandys, Natalya Lisovska, Barbara Bobek-Billewicz, Ewa Chmielik, Michał Jarząb   +11 more
doaj   +1 more source

MMP-7 is a predictive biomarker of disease progression in patients with idiopathic pulmonary fibrosis

ERJ Open Research, 2017
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with poor prognosis, which is characterised by destruction of normal lung architecture and excessive deposition of lung extracellular matrix.
Y. Bauer, E. White, Simon de Bernard, P. Cornelisse, I. Leconte, A. Morganti, S. Roux, O. Nayler   +7 more
semanticscholar   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Clinically feasible automated MRI volumetry of the brain as a prognostic marker in subjective and mild cognitive impairment

Frontiers in Neurology
Background/aimsThe number of patients suffering from cognitive decline and dementia increases, and new possible treatments are being developed. Thus, the need for time efficient and cost-effective methods to facilitate an early diagnosis and prediction ...
Rachel Amland, Rachel Amland, Rachel Amland, Geir Selbæk, Geir Selbæk, Geir Selbæk, Anne Brækhus, Anne Brækhus, Anne Brækhus, Trine H. Edwin, Knut Engedal, Anne-Brita Knapskog, Ellen Regine Olsrud, Karin Persson, Karin Persson   +14 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Temporal trends in colorectal cancer mortality rates (1999–2022) in the United States

Cancer Reports
Colorectal cancer (CRC) ranks as the third leading cause of cancer‐related deaths in the United States (U.S.). Our study aims to analyze CRC mortality patterns in the U.S., focusing on gender and age groups from 1999 to 2022.
Fariha Ilyas, Eiman Ahmed, Hassam Ali, Maheen Ilyas, Shiza Sarfraz, Mahnoor Khalid, Muhammad Khalaf, Prashant Reddy Mudireddy   +7 more
doaj   +1 more source

Exploring the gut microbiome’s role in colorectal cancer: diagnostic and prognostic implications

Frontiers in Immunology
The intricate interplay between the gut microbiome and colorectal cancer (CRC) presents novel avenues for early diagnosis and prognosis, crucial for improving patient outcomes.
Guoming Chen, Qing Ren, Zilan Zhong, Qianfan Li, Zhiqiang Huang, Cheng Zhang, Hongchao Yuan, Zixin Feng, Bonan Chen, Ning Wang, Yibin Feng   +10 more
doaj   +1 more source

Prevalence of Hepatitis B co-infection amongst HIV infected children attending a care and treatment centre in Owerri, South-eastern Nigeria

The Pan African Medical Journal, 2013
INTRODUCTION: Hepatitis B infection impacts negatively on disease progression in HIV infected children thereby increasing morbidity and mortality. In spite of the foregoing, data on Hepatitis B co-infection in children living with HIV in South Eastern ...
Emeka Nwolisa, Francis Mbanefo, Joseph Ezeogu, Paul Amadi   +3 more
doaj   +1 more source

Surgery as deterrent to progression of coronary artery disease [PDF]

, 1975
Rose Marie Lee
openalex   +1 more source