Results 31 to 40 of about 932,172 (297)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Modeling Lyme disease transmission

Infectious Disease Modelling, 2017
Lyme disease, a typical tick-borne disease, imposes increasing global public health challenges. A growing body of theoretical models have been proposed to better understand various factors determining the disease risk, which not only enrich our understanding on the ecological cycle of disease transmission but also promote new theoretical developments ...
Lou, Y, Wu, J
openaire   +4 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Emerging Human Fascioliasis in India: Review of Case Reports, Climate Change Impact, and Geo-Historical Correlation Defining Areas and Seasons of High Infection Risk

Tropical Medicine and Infectious Disease
The trematodes Fasciola hepatica and F. gigantica are transmitted by lymnaeid snails and cause fascioliasis in livestock and humans. Human infection is emerging in southern and southeastern Asia.
Santiago Mas-Coma, Pablo F. Cuervo, Purna Bahadur Chetri, Timir Tripathi, Albis Francesco Gabrielli, M. Dolores Bargues   +5 more
doaj   +1 more source

Forests and emerging infectious diseases: unleashing the beast within

Environmental Research Letters, 2020
Deforestation and associated changing landscapes are major components of environmental changes, with important implications for ecosystem functioning and biodiversity conservation. Tropical forests are hot spots of biodiversity and provide multiple goods
Jean-François Guégan, Ahidjo Ayouba, Julien Cappelle, Benoît de Thoisy   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Aerosols modification with H2O2 reduces airborne contamination by dental handpieces

Journal of Oral Microbiology, 2021
Objective: We designed an in vitro study to evaluate the efficiency of an 0.5 vol% hydrogen peroxide-based spray in reducing Coronavirus 229E spread during a conventional dental procedure. Methods: A class III cabinet-like chamber was custom-built, using
Andrei Cristian Ionescu, Eugenio Brambilla, Lamberto Manzoli, Giovanna Orsini, Valentina Gentili, Roberta Rizzo   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Analysis of Reported Cases of Giardia lamblia and Cryptosporidium spp. Infection in Children from Aragón (Northeast Spain) During the Period (2012–2021)

Microorganisms
Giardiasis and cryptosporidiosis, caused by Giardia lamblia and Cryptosporidium spp., are parasitic infections transmitted through faecal–oral routes or contaminated water.
Laura Lafarga-Molina, Encarnación Rubio, Cristina Seral, Antonio Rezusta, Pilar Egido Lizán, Carmen Malo Aznar, Josep-Oriol Casanovas-Marsal, María Teresa Fernández Rodrigo, Pilar Goñi   +8 more
doaj   +1 more source