Results 51 to 60 of about 7,199,284 (318)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A Bayesian inference framework to reconstruct transmission trees using epidemiological and genetic data [PDF]

, 2012
The accurate identification of the route of transmission taken by an infectious agent through a host population is critical to understanding its epidemiology and informing measures for its control. However, reconstruction of transmission routes during an
King, D.P., Soubeyrand, S., Daniel T Haydon, Marco J. Morelli (118948), Donald P. King, Morelli, Marco J., Thébaud, G., Soubeyrand, Samuel, Thébaud, Gael, Marco J. Morelli, Joël Chadœuf, Chadœuf, J., Haydon, Daniel T., King Donald P., Soubeyrand Samuel, Morelli Marco J., Donald P King, Joël Chadœuf (118955), Daniel T. Haydon, Morelli, M.J., Thébaud Gaël, Chadoeuf, Joel, Haydon, D.T., Samuel Soubeyrand (118964), Morelli , Marco J., Marco J Morelli, Donald P. King (116717), Gaël Thébaud (118951), Chadœuf Joël, King, Donald P., Daniel T. Haydon (118960), Gaël Thébaud, Haydon Daniel T., Samuel Soubeyrand   +33 more
core   +1 more source

Virulence and Host Range of Fungi Associated With the Invasive Plant Ageratina adenophora

Frontiers in Microbiology, 2022
To determine whether disease-mediated invasion of exotic plants can occur and whether this increases the risk of disease transmission in local ecosystems, it is necessary to characterize the species composition and host range of pathogens accumulated in ...
Lin Chen, Lin Chen, Ai-Ling Yang, Yu-Xuan Li, Han-Bo Zhang   +4 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

A quantitative analysis of transmission efficiency versus intensity for malaria. [PDF]

, 2010
The relationship between malaria transmission intensity and efficiency is important for malaria epidemiology, for the design of randomized control trials that measure transmission or incidence as end points, and for measuring and modelling malaria ...
Chiyaka, Christinah, Smith, DL, Drakeley, Chris J, Chiyaka, C, Smith, David L, David L. Smith, Chris J. Drakeley, Simon I. Hay, Hay, Simon I, Drakeley, CJ, Christinah Chiyaka, Hay, SI   +11 more
core   +1 more source

Analysis of Reported Cases of Giardia lamblia and Cryptosporidium spp. Infection in Children from Aragón (Northeast Spain) During the Period (2012–2021)

Microorganisms
Giardiasis and cryptosporidiosis, caused by Giardia lamblia and Cryptosporidium spp., are parasitic infections transmitted through faecal–oral routes or contaminated water.
Laura Lafarga-Molina, Encarnación Rubio, Cristina Seral, Antonio Rezusta, Pilar Egido Lizán, Carmen Malo Aznar, Josep-Oriol Casanovas-Marsal, María Teresa Fernández Rodrigo, Pilar Goñi   +8 more
doaj   +1 more source

Prevention of Cryptosporidium and GIARDIA at the Human/Gorilla/Livestock Interface

Frontiers in Public Health, 2018
Mountain gorillas (Gorilla beringei beringei) are critically endangered and found in Bwindi Impenetrable Forest and Virunga Volcanoes. Habitat destruction, high human population growth rates, poverty, and disease are threatening the survival of mountain ...
Gladys Kalema-Zikusoka, Stephen Rubanga, Birungi Mutahunga, Ryan Sadler   +3 more
doaj   +1 more source

Optimal COVID-19 Vaccine Sharing Between Two Nations That Also Have Extensive Travel Exchanges

Frontiers in Public Health, 2021
Countries around the world have observed reduced infections from the SARS-CoV-2 virus, that causes COVID-19 illness, primarily due to non-pharmaceutical interventions (NPIs) such as lockdowns and social distancing measures designed to limit physical ...
Chris Huntingford, Thomas Rawson, Michael B. Bonsall   +2 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

The risk of disease to great apes : Simulating disease spread in orang-utan (pongo pygmaeus wurmbii) and chimpanzee (pan troglodytes schweinfurthii) association networks [PDF]

, 2014
All great ape species are endangered, and infectious diseases are thought to pose a particular threat to their survival. As great ape species vary substantially in social organisation and gregariousness, there are likely to be differences in ...
Zuberbühler Klaus, Zuberbühler, Klaus, Julia Lehmann, Charlotte Carne, Helen Morrogh-Bernard, Lehmann, Julia, Semple Stuart, Semple, Stuart; id_orcid, Semple, Stuart, Carne Charlotte, Klaus Zuberbühler, Morrogh-Bernard Helen, Carne, Charlotte, Morrogh-Bernard, Helen, Lehmann, Julia; id_orcid, Lehmann Julia, Stuart Semple, Zuberbuehler, Klaus   +17 more
core   +1 more source