Results 61 to 70 of about 1,832,821 (308)

MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity. [PDF]

, 2017
Presynaptic homeostatic plasticity (PHP) controls synaptic transmission in organisms from Drosophila to human and is hypothesized to be relevant to the cause of human disease.
Davis, Graeme W, Dickman, Dion K, Fetter, Richard D, Genç, Özgür, Ma, Wenpei, Tong, Amy   +5 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Analysis of Reported Cases of Giardia lamblia and Cryptosporidium spp. Infection in Children from Aragón (Northeast Spain) During the Period (2012–2021)

Microorganisms
Giardiasis and cryptosporidiosis, caused by Giardia lamblia and Cryptosporidium spp., are parasitic infections transmitted through faecal–oral routes or contaminated water.
Laura Lafarga-Molina, Encarnación Rubio, Cristina Seral, Antonio Rezusta, Pilar Egido Lizán, Carmen Malo Aznar, Josep-Oriol Casanovas-Marsal, María Teresa Fernández Rodrigo, Pilar Goñi   +8 more
doaj   +1 more source

Prevention of Cryptosporidium and GIARDIA at the Human/Gorilla/Livestock Interface

Frontiers in Public Health, 2018
Mountain gorillas (Gorilla beringei beringei) are critically endangered and found in Bwindi Impenetrable Forest and Virunga Volcanoes. Habitat destruction, high human population growth rates, poverty, and disease are threatening the survival of mountain ...
Gladys Kalema-Zikusoka, Stephen Rubanga, Birungi Mutahunga, Ryan Sadler   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

RELATIONSHIP BETWEEN CLIMATE VARIABLES AND DENGUE INCIDENCE IN WEST INDONESIA

Jurnal Kedokteran Diponegoro
Background: Dengue fever is a major public health problem, especially in heavily populated metropolitan areas like Palembang City, Indonesia. Gaining insight into the impact of climatic conditions on the dynamics of dengue transmission is essential for ...
Ahmad Ghiffari, Ratika Febriani, Galuh Pratama Mynanda, Thia Prameswarie   +3 more
doaj   +1 more source

Multifocal Avian Influenza (H5N1) Outbreak

Emerging Infectious Diseases, 2007
During March 2006, an outbreak of highly pathogenic avian influenza (H5N1) occurred in multiple poultry farms in Israel. The epidemiologic investigation and review of outbreak mitigation efforts uncovered gaps in planning for and containing the outbreak,
Ran D. Balicer, Shmuel Reznikovich, Elyakum Berman, Michael Pirak, Amnon Inbar, Shimon Pokamunski, Itamar Grotto   +6 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Intractable policy failure: the case of bovine TB and badgers [PDF]

, 2009
The failure to eliminate bovine TB from the English and Welsh cattle herd represents a long-term intractable policy failure. Cattle-to-cattle transmission of the disease has been underemphasised in the debate compared with transmission from badgers ...
Assembly Welsh, Dunnet G., Edelman M., House of Commons, House of Commons, Independent Scientific Group, King D., Ministry of Agriculture, Fisheries and Food, NA PRO: HO 285/40b, NA PRO: MAF 459/12, NA PRO: MAF 459/16, NA PRO: MAF 459/37, NA PRO: MAF 459/66, Schön D. A., Wilkinson K., Woods A., Wyn Grant, Zuckerman Lord   +17 more
core   +1 more source