Results 131 to 140 of about 5,463,122 (264)

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

New technologies for identification and surveillance of Chagas disease vectors. [PDF]

Rev Soc Bras Med Trop
Gurgel-Gonçalves R, Julião GR, Ferreira RA, Souza RCM, Rojas-Cortez M, Vieira TM, Miranda VL, Brant JL, Obara MT, Silva RAE, Ibarrola-Vannucci AK, Marti G, Ceccarelli S.   +12 more
europepmc   +1 more source

First evidence of gonadal hybrid dysgenesis in Chagas disease vectors (Hemiptera, Triatominae): gonad atrophy prevents events of interspecific gene flow and introgression. [PDF]

Parasit Vectors, 2023
Azevedo LMS, Cesaretto NR, de Oliveira J, Ravazi A, Dos Reis YV, Tadini SCAF, da Silva Masarin I, Borsatto KC, Galvão C, da Rosa JA, de Azeredo-Oliveira MTV, Alevi KCC.   +11 more
europepmc   +1 more source

Spatial Control of Light‐Responsive Proteins and Optogenetics Within Hydrogels via Volumetric Bioprinting

Advanced Materials, EarlyView.
Spatiotemporal control over cell behavior within bioprinted constructs remains a key challenge in biofabrication. Volumetric bioprinting using multi‐wavelength light sources permits to activate light‐sensitive intracellular proteins as well as optogenetic gene and protein expression circuits in bioprinted cells, in addition to enabling fast printing of
Davide Ribezzi, Pere Català, Gabriel Größbacher, Paulina Nuñez Bernal, Olaf Nijssen, Sammy Florczak, Wilco Nijenhuis, Nuria Crusellas‐Villorbina, Bram Nijhoff, Paul Delrot, Jos Malda, Andreas Hierholzer, Martin Fussenegger, Lukas C. Kapitein, Riccardo Levato   +14 more
wiley   +1 more source

An immune system for the city: A cluster-randomized trial of a new paradigm for surveillance and control of disease vectors. [PDF]

PLoS Negl Trop Dis
Levy MZ, Tamayo LD, Condori-Pino CE, Arevalo-Nieto C, Castillo-Neyra R, Paz-Soldán VA.   +5 more
europepmc   +1 more source

Evaluation of the Effectiveness of Chemical Control for Chagas Disease Vectors in Loja Province, Ecuador. [PDF]

Vector Borne Zoonotic Dis, 2022
Grijalva MJ, Villacís AG, Ocaña-Mayorga S, Yumiseva CA, Nieto-Sanchez C, Baus EG, Moncayo AL.   +6 more
europepmc   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

The molecular biology of disease vectors collection: celebrating the tenth workshop on genetics, molecular biology, and control of insect vectors of tropical diseases (the Entomol). [PDF]

Parasit Vectors
Brandão-Filho SP, Silva-Filha MHNL, Dantas-Torres F.   +2 more
europepmc   +1 more source

Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors. [PDF]

Front Chem, 2021
Demarque DP, Espindola LS.
europepmc   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source