Results 111 to 120 of about 348,589 (256)

In-silico study: Hm86 protein of Hyalomma marginatum (Ixodida) as a candidate to provide anti-tick vaccine

Scientific Reports
Hyalomma marginatum is a major vector of Crimean-Congo hemorrhagic fever virus in Iran, posing serious threats to public health and livestock. With no effective vaccine currently available, recent studies have focused on identifying molecular targets for
Marziae Shahriari-Namadi, Kourosh Azizi, Hamzeh Alipour   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Tsunami impacts on shallow groundwater and associated water supply on the East Coast of Sri Lanka: a post-tsunami well recovery support initiative and an assessment of groundwater salinity in three areas of Batticaloa and Ampara Districts [PDF]

Groundwater, Aquifers, Salinity, Natural disasters, Water supply, Drinking water, Wells, Rehabilitation, Mosquitoes, Disease vectors, Environmental Economics and Policy, Health Economics and Policy, Resource /Energy Economics and Policy,
Amalraj, N., Amerasinghe, Priyani H., Burgi, N., Indrajith, N.G., Jeyakumar, P., Lionelrathne, D.M.D.S., Panabokke, Christopher Rajendra, Pathirana, S.R.K., Prathepaan, S., Villholth, K.G., Weerasinghe, M.D., Woolley, Olivia   +11 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Parasite spill-back from domestic hosts may induce an Allee effect in wildlife hosts [PDF]

, 2012
The exchange of native pathogens between wild and domesticated animals can lead to novel disease dynamics. A simple model reveals that the spill-back of native parasites\ud from domestic to wild hosts may cause a demographic Allee effect.
Ashander, J., Krkošek, M., Lewis, M. A.
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Molecular Prevalence of Blastocystis sp. from Patients with Diarrhea in the Republic of Korea

Microorganisms
Blastocystis sp. is the most common intestinal protozoan affecting human health worldwide. Several studies have reported the prevalence of Blastocystis sp. in various regions of the Republic of Korea. However, limited data are available on the prevalence
Ji-Young Kwon, Jong-Hoon Choi, Hee-Il Lee, Jung-Won Ju, Myoung-Ro Lee   +4 more
doaj   +1 more source

Water and poverty linkages: case studies from Nepal, Pakistan and Sri Lanka - Project report 1 [PDF]

Water resource management / Water harvesting / Poverty / Hydroelectric schemes / Water potential / Irrigation water / Population / Sanitation / Food security / Waterborne diseases / Disease vectors / Public health / Soil degradation / Drought / Case ...
Giordano, Mark, Hussain, Intizar
core  

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source