Results 111 to 120 of about 383,949 (313)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Multicomponent nanoparticles as nonviral vectors for the treatment of Fabry disease by gene therapy [PDF]

, 2012
Aritz Pérez Ruiz de Garibay, Diego Delgado, Ana del Pozo-Rodríguez, María Ángeles Solinís, Alicia Rodríguez GascónPharmacokinetics, Nanotechnology and Gene Therapy Group ...
del Pozo-Rodríguez A, Gascón AR, Ruiz de Garibay AP, Delgado D, Solinís MA   +4 more
core  

Leishmania chitinase facilitates colonization of sand fly vectors and enhances transmission to mice [PDF]

, 2008
Chitinases of trypanosomatid parasites have been proposed to fulfil various roles in their blood-feeding arthropod vectors but so far none have been directly tested using a molecular approach.
Joshi, M. B., Hajmova, M., Hajmová, Martina, Sadlova, Jovana, Volf, Petr, Rogers, Matthew E., Dwyer, D. M., Rogers, Matthew E, Bates, Paul, Sadlova, J., Volf, P., Joshi, Manju B, Dwyer, Dennis M, Bates, Paul A   +13 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Current Status of Trypanosoma grosi and Babesia microti in Small Mammals in the Republic of Korea

Animals
Small mammals, such as rodents and shrews, are natural reservoir hosts of zoonotic diseases, including parasitic protozoa. To assess the risk of rodent-borne parasitic protozoa in the Republic of Korea (ROK), this study investigated the status of ...
Hyun Jung Kim, BoGyeong Han, Hee-Il Lee, Jung-Won Ju, Hyun-Il Shin   +4 more
doaj   +1 more source

Arthropods as vectors of transmissible diseases in Spain

Medicina Clínica (English Edition), 2018
Different aspects related to globalization together with the great capacity of the arthropod vectors to adapt to a changing world favour the emergence and reemergence of numerous infectious diseases transmitted by them. Diptera (mosquitoes and sandflies), ticks, fleas and lice, among others, cause a wide spectrum of diseases with relevance in public ...
Portillo, Arantza, Ruiz Arrondo, Ignacio, Oteo, José A.   +2 more
openaire   +5 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

IMPACT OF HOUSE DESIGN ON THE ENTRY AND EXIT OF INSECT DISEASE VECTORS IN THE GAMBIA [PDF]

, 2010
The impact of house design on the entry and exit of insect vectors of disease in The Gambia House design may affect the exposure of the residents to vector-borne diseases in rural areas in Africa.
NJIE, MBYE
core  

Certifying the interruption of Chagas disease transmission by native vectors: cui bono? [PDF]

, 2013
Certifying the absence of Chagas disease transmission by native vectors lacks scientific grounds and weakens long-term control-surveillance systems to the detriment of people living under risk conditions.
Gurtler, Ricardo Esteban, Franch, Fernando Abad, Gürtler, Ricardo E., Liléia Diotaiuti, Diotaiuti, Liléia, Rodrigo Gurgel-Gonçalves, Gonçalves, Rodrigo Gurgel, Ricardo E Gürtler, Gurgel-Gonçalvez, Rodrigo, Fernando Abad-Franch, Abad-Franch, Fernando   +10 more
core   +1 more source

Travel and disease vector ticks

Travel Medicine and Infectious Disease, 2011
There are approximately twenty species of hard (ixodid) ticks worldwide that frequently affect human populations, many of which are associated with serious, sometimes fatal disease(s). When a tick travel souvenir is presented in the clinic, the risk must be immediately assessed by identifying the tick in question, ascertaining its disease vector status
openaire   +2 more sources