Results 91 to 100 of about 383,949 (313)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

First report on the molecular phylogenetics and population genetics of Aedes aegypti in Iran

Parasites & Vectors
Background Aedes aegypti, the primary vector of various human arboviral diseases, is a significant public health threat. Aedes aegypti was detected in Iran in 2018, in Hormozgan province, but comprehensive information regarding its genetic diversity and ...
Azim Paksa, Kourosh Azizi, Saideh Yousefi, Sorna Dabaghmanesh, Saeed Shahabi, Alireza Sanei-Dehkordi   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Culicid Mosquitoes as Vectors of Disease Agents in Europe [PDF]

, 2014
The chikungunya fever epidemic in northern Italy in 2007 and the recent demonstration of the introduction of various exotic mosquito species alerted the European nations to a growing risk of invasion by vector mosquitoes and outbreaks of mosquito-borne ...
Kronefeld, Mandy, Werner, D., Kampen, Helge   +2 more
core   +1 more source

Scorpion species distribution and sting epidemiology in Dena and Boyer-Ahmad, Iran – Implications for management

Parasite Epidemiology and Control
Scorpion envenomation represents a significant public health burden in Iran, particularly in Kohgiluyeh and Boyer-Ahmad Province, which reports 40,000 to 50,000 cases annually.
Mohsen Fakhraei, Raziyeh Shahheidari, Amir Hossein Roozitalab, Kourosh Azizi, Mohsen Kalantari   +4 more
doaj   +1 more source

Disease Vectors [PDF]

Environmental Health Insights, 2014
Stephanie L. Richards, Marilyn O. Ruiz, Rebecca T. Trout Fryxell, Christopher J. Vitek   +3 more
openaire   +4 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Crimean-Congo hemorrhagic fever viral RNA-free hard ticks infesting livestock in a rural region of southern Iran

Parasite Epidemiology and Control
Tick-borne viral diseases, including Crimean-Congo hemorrhagic fever (CCHF), are often fatal infectious diseases if left untreated. They impose a significant burden of morbidity on human health.
Parisa Moazzeni, Mohammad Djaefar Moemenbellah-Fard, Hamzeh Alipour, Ali Dianat, Marzieh Shahriari-Namadi   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Epicuticular lipids induce aggregation in Chagas disease vectors [PDF]

, 2014
Background. The triatomine bugs are vectors of the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. Aggregation behavior plays an important role in their survival by facilitating the location of refuges and cohesion of ...
Mijailovsky, Sergio Javier, Juárez, Marta Patricia, Girotti, Juan Roberto, Lorenzo Figueiras, Alicia N., Juárez, Patricia   +4 more
core