Results 91 to 100 of about 382,062 (313)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Epicuticular lipids induce aggregation in Chagas disease vectors [PDF]

, 2014
Background. The triatomine bugs are vectors of the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. Aggregation behavior plays an important role in their survival by facilitating the location of refuges and cohesion of ...
Mijailovsky, Sergio Javier, Juárez, Marta Patricia, Girotti, Juan Roberto, Lorenzo Figueiras, Alicia N., Juárez, Patricia   +4 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Nationwide surveillance detects yellow fever and chikungunya viruses in multiple Aedes mosquito species in Nigeria

Parasites & Vectors
Background Since the reemergence of yellow fever in 2017, the Nigeria Centre for Disease Control (NCDC) has been coordinating responses to local outbreaks with the support of the World Health Organization (WHO).
Udoka C. Nwangwu, Harouna Soumare, Judith U. Oguzie, William E. Nwachukwu, Cosmas O. Onwude, Festus A. Dogunro, Mawlouth Diallo, Chukwuebuka K. Ezihe, Nneka O. Agashi, Emelda I. Eloy, Stephen O. Anokwu, Clementina C. Anioke, Linda C. Ikechukwu, Chukwuebuka M. Nwosu, Oscar N. Nwaogo, Ifeoma M. Ngwu, Rose N. Onyeanusi, Angela I. Okoronkwo, Francis U. Orizu, Monica O. Etiki, Esther N. Onuora, Peter C. Okeke, Okechukwu C. Chukwuekezie, Josephine C. Ochu, Anise N. Happi, Sulaiman S. Ibrahim, Adetifa Ifedayo, Chikwe Ihekweazu, Christian T. Happi   +28 more
doaj   +1 more source

Genotype-Specific Vector Competence of Aedes albopictus for Japanese Encephalitis Virus Genotypes I, III, and V

Viruses
Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, poses a significant public health threat in Asia. Although Culex species are primary vectors, the role of Aedes albopictus in JEV transmission has gained attention under changing ecological ...
Bo-Ram Yun, Ji-Young Kwon, Dongmi Kwak, Hee Il Lee   +3 more
doaj   +1 more source

Lentiviral manipulation of gene expression in human adult and embryonic stem cells [PDF]

, 2006
Human stem cells could revolutionize the field of medicine by providing a diverse range of cell types for tissue replacement therapies and drug discovery.
Joanne Crossley, Crossley, J., Andrew Godfrey, Takeuchi, Y., Clements, M.O., Boshoff, C., Godfrey, A., Mark O. Clements, Sam J. Wilson, Wilson, S.J., Yasu Takeuchi, Chris Boshoff   +11 more
core   +1 more source

Recommendation On Vectors And Vector-Transmitted Diseases

, 2009
NL; nl; vwaefsafocalpoint@vwa ...
openaire   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Humoral response to mosquito salivary proteins as serological indicator of exposure to disease vectors: IgG response to the Anopheles gambiae gSG6 and malaria.

, 2009
Saliva of hematophagous arthropods, injected into the vertebrate during blood feeding, triggers the production of anti-saliva IgG and IgE antibodies. This host immune response to vector saliva (from ticks, sand flies, triatomines, tsetse and mosquitoes ...
Modiano D., ARCA', BRUNO, Verra F., Nebié I., Petrarca V., Sirima B. S., Mangano V., RONCA, RAFFAELE, FIORENTINO, GABRIELLA, Remoue F., Rizzo C., Poinsignon A., Coluzzi M.   +12 more
core   +1 more source