Results 81 to 90 of about 5,463,122 (264)
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Resistencia de los vectores de enfermedades a los plaguicidas : 15 informe del Comité de Expertos de la OMS en Biología de los Vectores y Lucha Antivectorial [se reunió en Ginebra del 5 al 12 de marzo de 1991] [PDF]
, 1992 62 p.Assesses the global status of vector resistance to pesticides and recommends a number of specific technical measures that can be used to prevent or delay the further spread of resistance. Addressed to specialists in entomology, the book concentrates
WHO Expert Committee on Vector Biology and Control +1 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Viral vectors : gene therapy and neuroscience applications /
, 1995 Genetic manipulation of the adult mammalian nervous system is one of the most exciting areas in contemporary neurobiology. The explosive growth of this field has been facilitated by harnessing the power of viruses to transfer genetic material into ...
Loewy, Arthur D., Kaplitt, Michael G.
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Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno +19 more
wiley +1 more source
Characterizing Convexity of Games using Marginal Vectors [PDF]
In this paper we study the relation between convexity of TU games and marginal vectors.We show that if specfic marginal vectors are core elements, then the game is convex.We characterize sets of marginal vectors satisfying this property, and we derive ...
Velzen, S. van +2 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu +10 more
wiley +1 more source
On sign-coherence of c-vectors
, 2018 Given a finite dimensional algebra A over an algebraically closed field, we consider the c-vectors such as defined by Fu in [18] and we give a new proof of its sign-coherence. Moreover, we characterise the modules whose dimension vectors are c-vectors as
Hipolito Treffinger (7747793)
core +2 more sources
, 2009 Saliva of hematophagous arthropods, injected into the vertebrate during blood feeding, triggers the production of anti-saliva IgG and IgE antibodies. This host immune response to vector saliva (from ticks, sand flies, triatomines, tsetse and mosquitoes ...
Modiano D. +12 more
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