Results 61 to 70 of about 348,589 (256)

Vector-Borne Diseases [PDF]

, 2019
Vector-borne diseases (VBDs) are illnesses caused by parasites, viruses or bacteria that are transmitted by a vector such as mosquitoes, ticks, sandflies, triatomine bugs, tsetse flies, fleas, black flies, aquatic snails and lice. In this chapter, we aim to show how climate change impacts VBDs and what role biodiversity (and its loss) plays for VBDs ...
Ruth Müller, Friederike Reuss, Vladimir Kendrovski, Doreen Montag   +3 more
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Leishmania major Infection in Synanthropic Rodents: Evidence for the Urbanization of Zoonotic Cutaneous Leishmaniasis (ZCL) in Southern Iran

Canadian Journal of Infectious Diseases and Medical Microbiology
Cutaneous leishmaniasis is of particular importance in southern Iran. This study aimed to investigate the infection of rodents with Leishmania major in an urban area of Fars Province, located in southern Iran.
Saeed Shahabi, Kourosh Azizi, Qasem Asgari, Bahador Sarkari   +3 more
doaj   +1 more source

On the Dynamics of Dengue Virus type 2 with Residence Times and Vertical Transmission

, 2016
A two-patch mathematical model of Dengue virus type 2 (DENV-2) that accounts for vectors' vertical transmission and between patches human dispersal is introduced. Dispersal is modeled via a Lagrangian approach.
Bichara, Derdei, Castillo-Chavez, Carlos, Holechek, Susan A., Murillo, Anarina L., Velazquez-Castro, Jorge   +4 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Identification of tickborne pathogens in cattle and sheep ticks from Kyrgyzstan using next-generation sequencing

Parasites & Vectors
Background Various tickborne diseases and pathogens in livestock have been reported in Kyrgyzstan; however, comprehensive molecular analyses from ticks and their tickborne pathogen diversity in the region are lacking.
Ji Ye Seo, Jin Seo Park, Bekbolsun Aknazarov, Hee Il Lee   +3 more
doaj   +1 more source

Mathematical Modelling of Mosquito Dispersal in a Heterogeneous Environment. [PDF]

, 2012
Mosquito dispersal is a key behavioural factor that affects the persistence and resurgence of several vector-borne diseases. Spatial heterogeneity of mosquito resources, such as hosts and breeding sites, affects mosquito dispersal behaviour and ...
Alonso, Angelina Mageni Lutambi, Arino, Arino, Bayoh, Beier, Blower, Britch, Britch, Cano, Cariboni, Chitnis, Chitnis, Clarke, Cummins, Depinay, Gething, Gu, Hay, Hoare, Jeefoo, Jin, Keeling, Killeen, Kirby, Knols, Le Menach, Le Menach, Li, Li, Manga, Martens, Meinsma, Melissa A. Penny, Midega, Minakawa, Mwandawiro, Nakul Chitnis, Ngwa, Nourridine, Okogun, Otero, Otero, O’Sullivan, Raffy, Saul, Service, Service, Smallegange, Smith, Smith, Stoddard, Takken, Tatem, Thomas Smith, Tran, van den Driessche, Vazquez-Prokopec, White, Yakob, Yaro   +60 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Anticipating the species jump: surveillance for emerging viral threats. [PDF]

, 2012
Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by what methods?
Bush, RM, Cobey, S, Flanagan, ML, Glass, GE, Leighton, TJ, Parrish, CR   +5 more
core   +1 more source