Results 51 to 60 of about 382,062 (313)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Monitoring of synthetic insecticides resistance and mechanisms among malaria vector mosquitoes in Iran: A systematic review

Heliyon, 2022
Background: In Iran, the prospect of malaria control relies mainly on insecticides used against the genus Anopheles (Diptera: Culicidae) as important vectors of malaria, arboviruses, and so on.
Ebrahim Abbasi, Mozaffar Vahedi, Masoumeh Bagheri, Saber Gholizadeh, Hamzeh Alipour, Mohammad Djaefar Moemenbellah-Fard   +5 more
doaj   +1 more source

Lentiviral Vectors in Huntington’s Disease Research and Therapy

, 2013
We describe here the potential of viral-mediated gene transfer for the modeling and treatment of Huntington's disease, focusing in particular on strategies for the tissue-specific targeting of various CNS cells.
Nicole Déglon, Noëlle Dufour, Déglon, N., Dufour, N., Aurélie Delzor, Delzor, A.   +5 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Phylogeny of Wolbachia strains in populations of Aedes aegypti and Culex pipiens in Hormozgan Province, South of Iran

Parasite Epidemiology and Control
Introduction: Aedes aegypti, and Culex pipiens are the primary vector of human arboviral diseases, which represent an important public health problem.
Alireza Sanei-Dehkordi, Amir Hossein Roozitalab, Saeed Shahabi, Mehrnaz Rahimi, Zahra Rousta, Raziyeh Shahheidari, Elahe Golestani, Azim Paksa   +7 more
doaj   +1 more source

Low sensitivity of ParaHIT-f rapid malaria test among patients with fever in rural health centers, Northern Tanzania

Journal of Infection in Developing Countries, 2011
Introduction: Several rapid diagnostic tools for malaria are currently available in local markets. However, diagnostic accuracy varies widely. The present study was conducted to evaluate a cheaply and easily available rapid diagnostic malaria test ...
Eliningaya John Kweka, Asanterabi Lowassa, Shandala Msangi, Epiphania E Kimaro, Ester E Lyatuu, Beda J Mwang'onde, Aneth M Mahande, Humphrey D Mazigo   +7 more
doaj   +1 more source

Evaluation of alternative mosquito sampling methods for malaria vectors in Lowland South - East Zambia. [PDF]

, 2013
Sampling malaria vectors and measuring their biting density is of paramount importance for entomological surveys of malaria transmission. Human landing catch (HLC) has been traditionally regarded as a gold standard method for surveying human exposure to ...
Gerry F Killeen, Sikaala, Chadwick, Aklilu Seyoum, Javan Chanda, Chanda, Javan, Seyoum, Aklilu, Miller, John M., Killeen, Gerry F., Killeen, Gerry, Russell, Tanya L, Sikaala, Chadwick H., Russell, Tanya L., Chadwick H Sikaala, Sikaala, Chadwick H, Dingani Chinula, Killeen, Gerry F, Miller, John M, Chinula, Dingani, John M Miller, Tanya L Russell   +19 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Species Diversity of Mosquitoes (Diptera: Culicidae) in Various Coastal Bioecological Regions of Southern Iran

Journal of Tropical Medicine
Blood-feeding mosquitoes (Diptera: Culicidae) impose a major public-health burden in tropical regions of the world. They transmit many pathogens to humans and domesticated animals.
Ebrahim Abbasi, Hamzeh Alipour, Shahyad Azari-Hamidian, Kourosh Azizi, Amirhossein Darabi, Sanaz Amiri, Hasan Bakhshi, Mohammad Darvishi, Mohammad Djaefar Moemenbellah-Fard   +8 more
doaj   +1 more source