Results 151 to 160 of about 6,137,711 (269)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Advancing the Development of the China-SCO Cooperation Center for Metabolic Diseases to Foster a Global Community of Health for All. [PDF]

J Diabetes
Ning G.
europepmc   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Current practices and challenges in the management of acute bacterial skin and skin structure infections (ABSSSI): results from an Italian multicentre survey with expert discussion. [PDF]

JAC Antimicrob Resist
Gazzola L, Augello M, Cavinato S, Briozzo A, D'Amico F, Schiano Moriello N, Segala FV, Frallonardo L, Di Gennaro F, Saracino A, Tacconi D, Gilio M, Frontuto M, Parruti G, Cattelan A, Marchetti G.   +15 more
europepmc   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The impact of China's drug regulatory reform on access to orphan drugs: a cross-sectional study of diseases listed in the rare disease catalog. [PDF]

Front Pharmacol
Lan Y, Lin X, Huang Z, Zan W.
europepmc   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Healthcare professionals' knowledge and views on unmet needs in prevention of infectious comorbidities in pregnant women with inflammatory rheumatic diseases. [PDF]

Rheumatol Int
Yerlanova D, Zimba O, Makhanbetkulova D, Nurmashev B, Korkosz M, Kocyigit BF.   +5 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Rapid response intervention for assessing health needs in newly arrived migrants in Catalonia: a community-based, descriptive study. [PDF]

BMJ Public Health
Gómez I Prat J, Martínez Alguacil H, Minguell Vergés S, Ouaarab Essadek H, García Circuns A, Garcia Rodriguez P, Garcia Sanchez S, Hamudy Khadim A, Seck G, Thiaow B, Serrano Roman M, Flores Mateo G, Ribó Ribalta J, Lopez Espinilla MDM, Sicart Torres E, Pequeño Saco S, Gavaldà Mestre L, Mendioroz J.   +17 more
europepmc   +1 more source