Results 281 to 290 of about 22,218,716 (335)

Digital health technology use in clinical trials of rare diseases: a systematic review. [PDF]

Commun Med (Lond)
Mao X, Zeng D, Wang X, Pearce DA, Baynam G, Chavannes NH, Chung WK, Wu H, Tham YC, Zhang S, Li G, Wong TY.   +11 more
europepmc   +1 more source

Genetic Association of Peptidoglycan Recognition Protein Variants with Inflammatory Bowel Disease

, 2013
Fareeha Zulfiqar, Iztok Hozo, Sneha Rangarajan, Roy A. Mariuzza, Roman Dziarski, Dipika Gupta   +5 more
openalex   +2 more sources

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Association Between Digestive Diseases, Nighttime Sleep, and Depressive Symptoms Among the Middle-Aged and Elderly Adults: A Mediation Analysis. [PDF]

JGH Open
Cheng C, Guo D, Cao X, Wang D, Li W, Miao B, Fei S.   +6 more
europepmc   +1 more source

Pooling Biomarker Data from Different Studies of Disease Risk, with a Focus on Endogenous Hormones

, 2010
Timothy J. Key, Paul N. Appleby, Naomi E. Allen, Gillian Reeves   +3 more
openalex   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

TET3-overexpressing macrophages are a unifying pathogenic feature with therapeutic potential in chronic inflammatory diseases. [PDF]

J Clin Invest
Haji S, Ogawa Y.
europepmc   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Adult NREM parasomnia and its health, social, and economic associations: a national matched-control study. [PDF]

Sleep Adv
Arvedsen S, Ibsen M, Frandsen R, Jennum PJ.   +3 more
europepmc   +1 more source

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source