Results 11 to 20 of about 45,703 (295)
DNA methylation and gene expression changes in monozygotic twins discordant for psoriasis: identification of epigenetically dysregulated genes. [PDF]
PLoS Genetics, 2012 Monozygotic (MZ) twins do not show complete concordance for many complex diseases; for example, discordance rates for autoimmune diseases are 20%-80%. MZ discordance indicates a role for epigenetic or environmental factors in disease.
Kristina Gervin +9 more
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A Novel Homozygous Mutation of Classic Bartter Syndrome Presenting with Renal Cysts in 6-year-Old Identical Twin Boys : A Case Report [PDF]
Childhood Kidney Diseases, 2021 Bartter syndrome is an autosomal recessive hypokalemic salt-losing tubulopathy, and classic Bartter syndrome is associated with mutations in the CLCNKB gene.
Min Hwa Son, Hyung Eun Yim, Kee Hwan Yoo
doaj +1 more source
Crohn's disease in monozygotic twins [PDF]
Postgraduate Medical Journal, 1986 Summary A pair of monozygotic twins with Crohn's disease is described. Both have ileocaecal disease and suffered their first symptoms after living apart for 6 years. The pathogenic role of hereditary and environmental factors is discussed in the light of this and previous reports of twins with Crohn's disease.
D S, Rampton, R B, Stott
openaire +2 more sources
Epigenetic Basis of Twin Discordance in Diseases: Future Benefits
Gynecology Obstetrics & Reproductive Medicine, 2018 Monozygotic twins share the same genotype since they are derived from the same zygote. However, monozygotic (MZ) twin siblings frequently present many phenotypic differences, such as their susceptibilities to diseases.
Ayse Banu Demir, Namik Demir
doaj +1 more source
Cells, 2022 Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. Investigating individuals with the most identical genetic background is optimal for minimizing the genetic contribution to gene expression.
Ekaterina I. Semenova +7 more
doaj +1 more source
Biomedicine & Pharmacotherapy, 1997 Besides familial Alzheimer's disease (AD), the genetic susceptibility has also been found in sporadic cases of AD, mostly related to the apolipoprotein E polymorphism. The penetrance of AD is determined by age and probably by environmental exposure. Gene-environment interaction of a disease can be examined through studies of twins.
I, Räihä +4 more
openaire +2 more sources
Kawasaki Disease in Monozygotic Twins [PDF]
Pediatric Infectious Disease Journal, 2011 Multiple lines of evidence suggest that susceptibility to Kawasaki disease (KD) is influenced by host genetics. Subclinical coronary artery vasculitis may be present in monozygotic twins who are discordant for clinical signs of KD. Health care providers should consider laboratory testing and echocardiography in both monozygotic twins when only one twin
Aubri, Kottek +2 more
openaire +2 more sources
Implante coclear na síndrome Kearns-Sayre: estudo de caso de irmãs gêmeas
Audiology: Communication Research, 2017 RESUMO A deficiência auditiva pode estar relacionada com diversos fatores, entre eles, a perda auditiva decorrente de determinadas síndromes genéticas.
Letícia Sampaio de Oliveira +3 more
doaj +1 more source
Metaverse and Healthcare: Machine Learning-Enabled Digital Twins of Cancer
Bioengineering, 2023 Medical digital twins, which represent medical assets, play a crucial role in connecting the physical world to the metaverse, enabling patients to access virtual medical services and experience immersive interactions with the real world.
Omid Moztarzadeh +6 more
doaj +1 more source
Isolated anorectal malformation with rectoperineal fistula in monozygotic twins
Journal of Pediatric Surgery Case Reports, 2019 Incidence of anorectal malformation (ARM) is reportedly 1 in approximately 2500–5000 live births. While its etiology remains elusive, most evidence indicates genetic factors to be the major cause.
Yuki Muta +3 more
doaj +1 more source