Results 11 to 20 of about 2,696,673 (357)
The Liability Threshold Model for Censored Twin Data [PDF]
, 2014 Family studies provide an important tool for understanding etiology of diseases, with the key aim of discovering evidence of family aggregation and to determine if such aggregation can be attributed to genetic components. Heritability and concordance estimates are routinely calculated in twin studies of diseases, as a way of quantifying such genetic ...
Hjelmborg, Jacob B. +2 more
arxiv +3 more sources
Development of the preterm gut microbiome in twins at risk of necrotising enterocolitis and sepsis [PDF]
, 2013 The preterm gut microbiome is a complex dynamic community influenced by genetic and environmental factors and is implicated in the pathogenesis of necrotising enterocolitis (NEC) and sepsis.
A Darfeuille-Michaud +49 more
core +21 more sources
Familial aggregation of multimorbidity in Sweden: national explorative family study
BMJ Medicine, 2023 Objectives To examine whether multimorbidity aggregates in families in Sweden.Design National explorative family study.Setting Swedish Multigeneration Register linked to the National Patient Register, 1997-2015.
Anders Halling +5 more
doaj +1 more source
DNA methylation and gene expression changes in monozygotic twins discordant for psoriasis: identification of epigenetically dysregulated genes. [PDF]
PLoS Genetics, 2012 Monozygotic (MZ) twins do not show complete concordance for many complex diseases; for example, discordance rates for autoimmune diseases are 20%-80%. MZ discordance indicates a role for epigenetic or environmental factors in disease.
Kristina Gervin +9 more
doaj +1 more source
Multicore disease in twins. [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1976 Multicore disease in identical twin boys presented in infancy as generalized weakness and torticollis. Motor milestones such as sitting, standing, and running were delayed, although by the age of 6 years marked improvement in muscle strength had occurred. Serum enzymes were normal.
Patiricia Duffner +3 more
openaire +3 more sources
A Twin Study of Perthes Disease [PDF]
Pediatrics, 2016 BACKGROUND: Legg-Calvé-Perthes disease (LCPD) is an idiopathic avascular necrosis of the femoral head. Its etiology is poorly understood, although previous studies have implicated low birth weight and possible genetic determinants. The aim of this study was to identify potential birth weight and genetic associations
Stephanie van Dijck +6 more
openaire +4 more sources
Cells, 2022 Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. Investigating individuals with the most identical genetic background is optimal for minimizing the genetic contribution to gene expression.
Ekaterina I. Semenova +7 more
doaj +1 more source
Metagenomic Analysis of the Structure and Function of the Human Gut Microbiota in Crohn's Disease [PDF]
, 2010 Inflammatory bowel diseases (IBD), such as Crohn’s disease, are chronic, immunologically mediated disorders that have severe medical consequences.
Claire M. Fraser-Liggett
core +2 more sources
Ageing And Cancer As Diseases Of Epigenesis [PDF]
, 2009 Cancer and ageing are often said to be diseases of development. During the past fifty years, the genetic components of cancer and ageing have been intensely investigated since development, itself, was seen to be an epiphenomenon of the genome.
Gilbert, Scott F.
core +2 more sources
Epigenetic Basis of Twin Discordance in Diseases: Future Benefits
Gynecology Obstetrics & Reproductive Medicine, 2018 Monozygotic twins share the same genotype since they are derived from the same zygote. However, monozygotic (MZ) twin siblings frequently present many phenotypic differences, such as their susceptibilities to diseases.
Ayse Banu Demir, Namik Demir
doaj +1 more source