Results 31 to 40 of about 45,570 (268)

Envisioning the Future of Personalized Medicine: Role and Realities of Digital Twins

Journal of Medical Internet Research
Digital twins have emerged as a groundbreaking concept in personalized medicine, offering immense potential to transform health care delivery and improve patient outcomes.
Alexandre Vallée
doaj   +1 more source

Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia

Clinical and Translational Medicine, 2017
Background Monozygotic twins are valuable in assessing the genetic vs environmental contribution to diseases. In the era of complete genome sequences, they allow identification of mutational mechanisms and specific genes and pathways that offer ...
C. A. Castellani, M. G. Melka, J. L. Gui, A. J. Gallo, R. L. O’Reilly, S. M. Singh   +5 more
doaj   +1 more source

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge, Maite E. Houwing, Rowena L. Grohssteiner, Ferdows Atiq, Sonja A. M. C. Teuben, Mirjam P. Fransen, Marjon H. Cnossen   +6 more
wiley   +1 more source

Artrogriposis múltiple congénita en gemelo monocoriónico biamniótico: Reporte de caso y revisión de la literatura A case report of arthrogryposis multiplex congenita in monochorionic biamniotic twins

Revista Colombiana de Obstetricia y Ginecología, 2009
Introducción: la artrogriposis múltiple congénita es un grupo de desórdenes musculoesqueléticos de muy rara aparición, caracterizados por contracturas múltiples articulares, en los que se afectan los músculos de los miembros superiores, inferiores y del ...
Felipe Ruiz-Botero, Harry Pachajoa, Wilmar Saldarriaga, Carolina Isaza   +3 more
doaj  

Crohn's disease in monozygotic twins [PDF]

Postgraduate Medical Journal, 1986
Summary A pair of monozygotic twins with Crohn's disease is described. Both have ileocaecal disease and suffered their first symptoms after living apart for 6 years. The pathogenic role of hereditary and environmental factors is discussed in the light of this and previous reports of twins with Crohn's disease.
D S, Rampton, R B, Stott
openaire   +2 more sources

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

Immune digital twins for complex human pathologies: applications, limitations, and challenges

npj Systems Biology and Applications
Digital twins represent a key technology for precision health. Medical digital twins consist of computational models that represent the health state of individual patients over time, enabling optimal therapeutics and forecasting patient prognosis.
Anna Niarakis, Reinhard Laubenbacher, Gary An, Yaron Ilan, Jasmin Fisher, Åsmund Flobak, Kristin Reiche, María Rodríguez Martínez, Liesbet Geris, Luiz Ladeira, Lorenzo Veschini, Michael L. Blinov, Francesco Messina, Luis L. Fonseca, Sandra Ferreira, Arnau Montagud, Vincent Noël, Malvina Marku, Eirini Tsirvouli, Marcella M. Torres, Leonard A. Harris, T. J. Sego, Chase Cockrell, Amanda E. Shick, Hasan Balci, Albin Salazar, Kinza Rian, Ahmed Abdelmonem Hemedan, Marina Esteban-Medina, Bernard Staumont, Esteban Hernandez-Vargas, Shiny Martis B, Alejandro Madrid-Valiente, Panagiotis Karampelesis, Luis Sordo Vieira, Pradyumna Harlapur, Alexander Kulesza, Niloofar Nikaein, Winston Garira, Rahuman S. Malik Sheriff, Juilee Thakar, Van Du T. Tran, Jose Carbonell-Caballero, Soroush Safaei, Alfonso Valencia, Andrei Zinovyev, James A. Glazier   +46 more
doaj   +1 more source

Comparison of Genomic and Epigenomic Expression in Monozygotic Twins Discordant for Rett Syndrome.

PLoS ONE, 2013
Monozygotic (identical) twins have been widely used in genetic studies to determine the relative contributions of heredity and the environment in human diseases.
Kunio Miyake, Chunshu Yang, Yohei Minakuchi, Kenta Ohori, Masaki Soutome, Takae Hirasawa, Yasuhiro Kazuki, Noboru Adachi, Seiko Suzuki, Masayuki Itoh, Yu-Ichi Goto, Tomoko Andoh, Hiroshi Kurosawa, Mitsuo Oshimura, Masayuki Sasaki, Atsushi Toyoda, Takeo Kubota   +16 more
doaj   +1 more source

Manifestation of Molar-Incisor Hypomineralisation in Twins: Clinical Case Reports

Brazilian Dental Science, 2013
Molar-incisor hypomineralisation is a qualitative defect of dental tissue of systemic origin affecting one or more permanent first molars and sometimes the permanent incisors as well.
Camila Maria Bullio Fragelli, Fabiano Jeremias, Lourdes Santos-Pinto   +2 more
doaj   +1 more source

Hyperbaric oxygen therapy of angiopathic changes in patients with inherited gene imbalance [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2007
Introduction Phenotype match inherited by genes is in most cases present in monozygotic twins. Their phenotypic resemblance is unfortunately characterized by strong susceptibility for the development of chronic non-infectious diseases.
Brkić Predrag, Mitrović Ana, Rakić Miodrag, Grajić Mirko, Jovanović Tomislav   +4 more
doaj   +1 more source