Results 61 to 70 of about 2,696,673 (357)
Revista Colombiana de Obstetricia y Ginecología, 2009 Introducción: la artrogriposis múltiple congénita es un grupo de desórdenes musculoesqueléticos de muy rara aparición, caracterizados por contracturas múltiples articulares, en los que se afectan los músculos de los miembros superiores, inferiores y del ...
Felipe Ruiz-Botero +3 more
doaj
The twin pillars of Disease Models & Mechanisms [PDF]
Disease Models & Mechanisms, 2021 ![Figure][1] New DMM Editor-in-Chief Elizabeth Patton. This past year, it has become painfully obvious how much we rely on scientific research to protect us from disease and develop the therapies that aid our recovery. We know that the impact of COVID-19 will be with us for some time.
openaire +4 more sources
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Gene Expression Profiles from Disease Discordant Twins Suggest Shared Antiviral Pathways and Viral Exposures among Multiple Systemic Autoimmune Diseases. [PDF]
PLoS ONE, 2015 Viral agents are of interest as possible autoimmune triggers due to prior reported associations and widely studied molecular mechanisms of antiviral immune responses in autoimmunity.
Lu Gan +7 more
doaj +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Epigenetics as an Explanation for Phenotypic Variation in Monozygotic Twins [PDF]
, 2011 The following is the introduction of this article: Researchers often use twins as natural samples to test hypotheses regarding the contribution of genetic factors to different phenotypes, especially diseases.
Pomerantseva, Marina
core +1 more source
Pili torti and multiple facial milia as an expression of ectodermal dysplasia in monozygotic twins
Przegląd Dermatologiczny, 2014 Introduction . Genodermatoses – congenital diseases with diverse clinical presentation – are caused by ectodermal defects. pili torti and milia may be features of these defects. Concomitantly these symptoms are present in rare genodermatoses: Bazex-Dupre-
Monika Sikorska +3 more
doaj +1 more source
Frontiers in Endocrinology, 2023 IntroductionPregnancy-associated plasma protein-A (PAPP-A) is an IGF-activating enzyme suggested to influence aging-related diseases. However, knowledge on serum PAPP-A concentration and regulation in elderly subjects is limited.
Rikke Hjortebjerg +10 more
doaj +1 more source
A Revolution of Personalized Healthcare: Enabling Human Digital Twin with Mobile AIGC [PDF]
arXiv, 2023 Mobile Artificial Intelligence-Generated Content (AIGC) technology refers to the adoption of AI algorithms deployed at mobile edge networks to automate the information creation process while fulfilling the requirements of end users. Mobile AIGC has recently attracted phenomenal attentions and can be a key enabling technology for an emerging application,
arxiv