Results 51 to 60 of about 5,431 (271)

Net effect of wealth on health for COVID-19 – worldwide state comparison

Rozwój Regionalny i Polityka Regionalna
The wealth-health relationship is not unambiguous and constant. Indeed, a higher level of wealth affects individual and population health in two opposite ways. Increased risk factors raise the probability of some diseases.
Agata Żółtaszek, Alicja Olejnik
doaj   +1 more source

Knowledge of cardiovascular risk factors among caretakers of outpatients attending a tertiary cardiovascular center in Tanzania: a cross-sectional survey

BMC Cardiovascular Disorders, 2020
Background Health literacy on cardiovascular diseases (CVDs) plays an effective role in preventing or delaying the disease onset as well as in impacting the efficacy of their management.
Pedro Pallangyo, Nsajigwa Misidai, Makrina Komba, Zabella Mkojera, Happiness J. Swai, Naairah R. Hemed, Henry Mayala, Smita Bhalia, Jalack Millinga, Upendo W. Mollel, Happiness L. Kusima, Ester Chavala, Ziada Joram, Halifa Abdallah, Rajabu Hamisi, Mohamed Janabi   +15 more
doaj   +1 more source

Metabolic Syndrome: A Multifaceted Disease of Affluence

Journal of Endocrinology and Metabolism, 2012
Metabolic syndrome developed in consequence of an evolutionary inadequacy: the human body was unprepared for a dietary excess of nutrients, especially lipids (largely in detriment of carbohydrate). This excess awakens metabolic signals akin to those of starvation, in which the main energy staple is the body"s own lipid reserve.
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Correlations between physical activity and quality of life in entrepreneurs from Wrocław, Poland

BMC Sports Science, Medicine and Rehabilitation, 2023
Background Limited physical activity is one of the main reasons for the rapid increase in the prevalence of diseases of affluence, which can lead to premature deaths in adults.
Daniel Puciato, Dawid Bączkowicz, Michał Rozpara   +2 more
doaj   +1 more source

Allergies and diabetes as risk factors for dengue hemorrhagic fever: results of a case control study. [PDF]

, 2010
BACKGROUND: The physiopathology of dengue hemorrhagic fever (DHF), a severe form of Dengue Fever, is poorly understood. We are unable to identify patients likely to progress to DHF for closer monitoring and early intervention during epidemics, so most ...
Maria Aparecida A. Figueiredo, Lima, José Wellington O, Costa, Maria CN, Teixeira, Maria Glória, Maria C. N. Costa, Maria Glória Teixeira, Laura C. Rodrigues, Morato, Vanessa, Maria C N Costa, Pedro F. C. Vasconcelos, Maria Aparecida A. Figueiredo, Barreto, Maurício L, Figueiredo, Maria Aparecida A, Maurício L Barreto, Ronald Blanton, Pedro F C Vasconcelos, Márcio R. T. Nunes, Maria Aparecida A Figueiredo, Maurício L. Barreto, Blanton, Ronald, Vanessa Morato, José Wellington O Lima, Laura C Rodrigues, Márcio R T Nunes, Vasconcelos, Pedro FC, Rodrigues, Laura C, José Wellington O. Lima, Nunes, Márcio RT   +27 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source