Results 31 to 40 of about 151,910 (215)

One Polish Center’s Experience of Catheter Ablation for Cardiac Arrhythmias in Dogs

Veterinary Sciences
Radiofrequency catheter ablation is a minimally invasive electrophysiological procedure that utilizes radiofrequency energy to induce targeted thermal injury within arrhythmogenic myocardial tissue, thereby eliminating the substrate responsible for rapid
Agnieszka Noszczyk-Nowak, Piotr Frydrychowski, Justyn Gach, Zuzanna Wojtczak, Alicja Cepiel-Kośmieja, Artur Fuglewicz, Krzysztof Nowak   +6 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Selected Large-Animal Models of Ventricular Arrhythmias

Biology
Ventricular arrhythmias are among the most life-threatening cardiac rhythm disturbances. Owing to their complex pathophysiology and high mortality risk, they remain a major focus of research aimed at elucidating underlying mechanisms and improving ...
Piotr Frydrychowski, Alicja Cepiel-Kośmieja, Zuzanna Wojtczak, Krzysztof Nowak, Agnieszka Noszczyk-Nowak   +4 more
doaj   +1 more source

Fatal pulmonary hemorrhage in a horse during bronchoalveolar lavage – single case report

BMC Veterinary Research, 2019
Background Pulmonary hemorrhage is a rare cause of death in horses. Hemorrhage within the respiratory tract has many causes, including mycosis of the guttural pouch, invasive procedures causing serious trauma to nasal conchae, or lung biopsy.
Mathilde S. Varegg, Kine M. Kløverød, Malin K. Austnes, Natalia Siwinska, Malwina Słowikowska, Agnieszka Zak, Janusz A. Madej, Malgorzata Kandefer-Gola, Rafal Ciaputa, Marcin Nowak, Artur Niedzwiedz   +10 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Histiocytic sarcoma in dogs: epidemiology, anatomopathology, and immunohistochemistry [PDF]

Pesquisa Veterinária Brasileira
: Histiocytic sarcomas have been described in veterinary medicine since 1980, but studies on the subject are still scarce. Based on this, the objective of this article is to describe the epidemiological, anatomopathological and immunohistochemical ...
Flávia S. Da Luz, Renata D. Mazaro, Gabriela Hartmann, Tereza Cristina Da Silva, Bruno Cogliati, Lilian R. Marques de Sá, Glaucia D. Kommers, Alexandre A. Tonin, Rafael A. Fighera   +8 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source