Results 51 to 60 of about 151,910 (215)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Aspectos imunoistoquímicos da hepatite infecciosa canina Immunohistochemical aspects of canine infectious hepatitis

Ciência Rural, 2008
Tecidos de 27 cães que morreram de hepatite infecciosa canina (HIC) foram avaliados por imunoistoquímica (IHQ) para detecção de antígeno de adenovírus canino tipo 1 (CAV-1), por meio de um anticorpo monoclonal. Os tecidos examinados incluíram fígado, rim,
Maria Andréia Inkelmann, Bruno Leite dos Anjos, Glaucia Denise Kommers, Rafael Almeida Fighera, Claudio Severo Lombardo de Barros   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Screening for circulating miR-208a and -b in different cardiac arrhythmias of dogs

Journal of Veterinary Research, 2018
In recent years, the high sensitivity and specificity of novel miRNA biomarkers have been utilised for early diagnosis and treatment monitoring of various diseases.
Noszczyk-Nowak Agnieszka, Zacharski Maciej, Michałek Marcin   +2 more
doaj   +1 more source

Adenocarcinoma uretral em uma cadela Urethral adenocarcinoma in a bitch

Ciência Rural, 2005
Tumores primários de uretra são raros em animais e há poucos relatos em cães. A ocorrência é maior em cadelas idosas, não havendo predileção por raça. Disúria, estrangúria e hematúria são sinais clínicos associados a esses tumores.
Marcia Cristina da Silva, Rafael Almeida Fighera, Tatiana Mello de Souza, Dominguita Lühers Graça, Claudio Severo Lombardo de Barros   +4 more
doaj   +1 more source

Serum total antioxidant capacity and enzymatic defence of dogs with chronic heart failure and atrial fibrillation: a preliminary study

Journal of Veterinary Research, 2020
Atrial fibrillation may potentially contribute to oxidative stress to a greater extent than chronic heart failure. The aim of the study was to compare the serum total antioxidant capacity and enzymatic antioxidant defence of dogs with chronic heart ...
Michałek Marcin, Tabiś Aleksandra, Noszczyk-Nowak Agnieszka   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Retrospective analysis of indications and complications related to implantation of permanent pacemaker: 25 years of experience in 31 dogs

Journal of Veterinary Research, 2019
Introduction: Pacemaker implantation is the only effective symptomatic treatment for life-threatening bradyarrhythmias. Major complications observed after implantation of cardiac pacemakers include lead dislocation, loss of pulse generator function, and ...
Noszczyk-Nowak Agnieszka, Michałek Marcin, Kapturska Karolina, Cepiel Alicja, Janiszewski Adrian, Pasławski Robert, Skrzypczak Piotr, Pasławska Urszula   +7 more
doaj   +1 more source

Mielolipoma adrenal bilateral em um cão Bilateral adrenal myelolipoma in a dog

Ciência Rural, 2008
O presente relato descreve um caso de mielolipoma adrenal bilateral em uma cadela Poodle de 13 anos de idade. O cão morreu por peritonite séptica aguda, decorrente de ulceração e perfuração intestinal por corpo estranho linear.
Silvia de Araújo França, Roselene Ecco, Roberto Mauricio Carvalho Guedes   +2 more
doaj   +1 more source