Results 71 to 80 of about 359,299 (301)

Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK [PDF]

, 2015
To describe the signalment, clinicopathological findings and outcome in dogs presenting with acute kidney injury (AKI) and skin lesions between November 2012 and March 2014, in whom cutaneous and renal glomerular vasculopathy (CRGV) was suspected and ...
ARDISSINO, ARDISSINO, ARONSON, BIRNBAUM, BLOMBERY, BOURHY, BOYCE, BURNENS, CARPENTER, CHANTREY, COWAN, DELL'ORCO, DICKINSON, EUBIG, FERRER, FISCHER, FOURNEL, GARCIA, GOLDFARB, GREENE, HENDRICKS, HERTZKE, HOLLOWAY, KAVANAGH, LI, MILFORD, MONAHAN, MOORE, MORRIS, MUNDAY, NORIS, PASS, REBAR, RENTKO, ROBY, ROTERMUND, RUGGENENTI, SALVADORI, SYKES, TANGEMAN, TARR, TARR, UCHIDA, VAN DEN INGH, VICTORIA, WAIKAR, WALKER   +46 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Correlation between semiautomated magnetic resonance imaging volumetry of the cingulate gyrus and interictal epileptiform discharge lateralization in dogs with idiopathic epilepsy

Journal of Veterinary Internal Medicine
Background Brain imaging suggests the involvement of the limbic system, particularly the cingulate gyrus (GC), in dogs with idiopathic epilepsy (IE). Hypothesis A correlation exists between the side of interictal epileptiform discharges (IEDs) and the ...
Aleksandra Banasik, Marcin Wrzosek, Paulina Drobot, Karolina Owsińska‐Schmidt, Laura Brewińska, Anna Zimny, Przemysław Podgórski   +6 more
doaj   +1 more source

Serum total antioxidant capacity and enzymatic defence of dogs with chronic heart failure and atrial fibrillation: a preliminary study

Journal of Veterinary Research, 2020
Atrial fibrillation may potentially contribute to oxidative stress to a greater extent than chronic heart failure. The aim of the study was to compare the serum total antioxidant capacity and enzymatic antioxidant defence of dogs with chronic heart ...
Michałek Marcin, Tabiś Aleksandra, Noszczyk-Nowak Agnieszka   +2 more
doaj   +1 more source

Tissue Cytokine Responses in Canine Visceral Leishmaniasis [PDF]

, 2001
To elucidate the local tissue cytokine response of dogs infected with Leishmania chagasi, cytokine mRNA levels were measured in bone marrow aspirates from 27 naturally infected dogs from Brazil and were compared with those from 5 uninfected control ...
Courtenay, O., Day, M.J., Dye, C., Garcez, L.M., Kaye, P.M., Quinnell, R.J., Shaw, M.-A.   +6 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Equine Asthma in a Comparative Perspective: Cardiovascular and Neurological Manifestations of Asthma Across Different Species

Animals
Asthma is a multifactorial respiratory disease that naturally occurs in horses, humans, and cats, presenting common clinical signs and species-specific mechanisms. This review addresses the impact of asthma on the cardiovascular and neurological systems,
Dorota Dlugopolska, Natalia Siwinska, Agnieszka Noszczyk-Nowak   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Genetic Basis of Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniel Dogs—A Review

Veterinary Sciences
Myxomatous mitral valve disease (MMVD) is the most prevalent cardiac disorder in small and toy breed dogs, with the Cavalier King Charles Spaniel (CKCS) showing exceptionally high predisposition and early onset of the disease.
Maksymilian Lewicki, Sylwia Barbara Górczyńska-Kosiorz, Piotr Frydrychowski, Zuzanna Sidoruk, Agnieszka Noszczyk-Nowak   +4 more
doaj   +1 more source

Integrating the landscape epidemiology and genetics of RNA viruses: rabies in domestic dogs as a model [PDF]

, 2012
Landscape epidemiology and landscape genetics combine advances in molecular techniques, spatial analyses and epidemiological models to generate a more real-world understanding of infectious disease dynamics and provide powerful new tools for the study of
Anderson, Cross, Cullingham, D. L. HORTON, Dietzschold, Eng, K. BRUNKER, K. HAMPSON, Knobel, McCallum, R. BIEK, Sharma, Swanepoel, Wandeler, Weiss, Windiyaningsih, Zanoni   +16 more
core   +2 more sources