Results 61 to 70 of about 107,257 (223)

Wireless, Deep‐Seeing Smart Pill: A NIR‐II Fluorescence Imaging Capsule Endoscope for Gastrointestinal Cancer

Advanced Science, EarlyView.
A novel near‐infrared‐II fluorescent imaging capsule endoscope that detects specific fluorescence signals above 900 nm enables highly sensitive, targeted imaging of gastrointestinal cancer tissue. This wirelessly powered and magnetically controlled “smart pill” achieves high sensitivity and deep tissue penetration, allowing precise, non‐invasive ...
Weicheng Wang, Jinlei Jiang, Zhengting Wang, Shuqi Liu, Wei Wang, Xi Chen, Qirui Zhao, Xinyuan Cui, Cheng Zhou, Shengsheng Cui, Daxiang Cui   +10 more
wiley   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Indices of heart rate variability for estimation of adaptive processes and stress resistance in gastroenterology practice (using up-to-date technology of precise-diagnosis)

Gastroenterologìa, 2020
A vast amount of works is devoted to studying the heart rate variability (HRV). The article covers a literature review on modern concepts about heart rate variability as a method for estimation of mechanisms of physiological functions regulation in a ...
Yu.M. Stepanov, E.V. Zyhalo
doaj   +1 more source

O-25 ASSESSMENT OF MODELS FOR PREDICTING RESPONSE TO CORTICOIDS TREATMENT IN ALCOHOL-ASSOCIATED HEPATITIS: A GLOBAL COHORT STUDY

Annals of Hepatology, 2023
Introduction and Objectives: Alcohol-associated hepatitis (AH) is a severe entity associated with high mortality. Corticosteroids might be used in cases with severe disease and several dynamic models can predict mortality and response to corticosteroids ...
Francisco Idalsoaga, Luis Antonio Díaz, Gustavo Ayares, Jorge Arnold, Winston Dunn, Yanming Li, Ashwani Singal, Doug Simonetto, María Ayala-Valverde, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes-López, Carolina A Ramirez, Dalia Morales-Arraez, Wei Zhang, Steve Qian, Joseph Ahn, Seth Buryska, Heer Mehta, Muhammad Waleed, Horia Stefanescu, Adelina Horhat, Andreea Bumbu, Bashar Attar, Rohit Grawal, Joaquín Cabezas, Inés García-Carrera, Berta Cuyàs, Maria Poca, German Soriano Pastor, Shiv K Sarin, Rakhi Maiwall, Prasun K Jalal, María Fátima Higuera-De La Tijera, Anand Kulkarni, Nagaraja Rao P, Patricia Guerra Salazar, Lubomir Skladaný, Natália Bystrianska, Veronica Prado, Ana Clemente-Sanchez, Diego Rincón, Tehseen Haider, Kristina R Chacko, Gustavo A Romero, Florencia D Pollarsky, Juan Carlos Restrepo, Luis G Toro, Pamela Yaquich, Manuel Mendizabal, Maria Laura Garrido, Sebastian Marciano, Melisa Dirchwolf, Victor Vargas, Cesar Jimenez, Guadalupe García-Tsao, Guillermo Ortiz, Juan G Abraldes, Patrick Kamath, Marco Arrese, Vijay Shah, Ramon Bataller, Juan Pablo Arab   +63 more
doaj   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

ASGE guideline for endoscopic full-thickness resection and submucosal tunnel endoscopic resection

VideoGIE, 2019
With the development of reliable endoscopic closure techniques and tools, endoscopic full-thickness resection (EFTR) is emerging as a therapeutic option for the treatment of subepithelial tumors and epithelial neoplasia with significant fibrosis.
Harry R. Aslanian, MD, FASGE, Amrita Sethi, MD, FASGE, Manoop S. Bhutani, MD, FASGE, Adam J. Goodman, MD, FASGE, Kumar Krishnan, MD, David R. Lichtenstein, MD, FASGE, Joshua Melson, MD, FASGE, Udayakumar Navaneethan, MD, Rahul Pannala, MD, MPH, FASGE, Mansour A. Parsi, MD, MPH, FASGE, Allison R. Schulman, MD, MPH, Shelby A. Sullivan, MD, Nirav Thosani, MD, Guru Trikudanathan, MBBS, MD, Arvind J. Trindade, MD, Rabindra R. Watson, MD, John T. Maple, DO, FASGE   +16 more
doaj   +1 more source

Microbial changes from bariatric surgery alters glucose-dependent insulinotropic polypeptide and prevents fatty liver disease

Gut Microbes, 2023
Bariatric surgery remains a potent therapy for nonalcoholic fatty liver disease (NAFLD), but its inherent risk and eligibility requirement limit its adoption.
Tien S. Dong, William Katzka, Julianne C. Yang, Candace Chang, Nerea Arias-Jayo, Venu Lagishetty, Anna Balioukova, Yijun Chen, Erik Dutson, Zhaoping Li, Emeran A. Mayer, Joseph R. Pisegna, Claudia Sanmiguel, Jonathan P. Jacobs   +13 more
doaj   +1 more source

Multiscale Spatial Fusion Feature‐Driven Characterization of Gastric Cancer Invasive Margins: A Multicenter Cohort Study for Preoperative Accurate Differentiation Between T4a and T4b Subtypes

Advanced Science, EarlyView.
This study develops a multi‐dimensional vision Transformer‐based model, GAVR, to accurately distinguish gastric cancer T4a/b stages preoperatively. Validated across multi‐center cohorts, it achieves excellent performance and significantly improves radiologists’ diagnostic accuracy, offering a promising tool for clinical decision‐making.
Guoliang Zheng, Xiaomiao Chai, Peng Jin, Xin Xin, Yingjie Li, Chun Yang, Jia Wei, Zishuo Yan, Jingyu Zhang, Qianning Zhao, Yingchen Han, Ning Zhang, Fuze Li, Bo Qiao, Huan Wang, Huachuan Zheng, Yan Li, Xin Zhang, Yan Zhao, Wenjun Mao, Jing Zhang   +20 more
wiley   +1 more source

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

MiR‐146a‐5p Suppresses M1 Polarization of Tumor‐Associated Macrophages via IRAK1/NF‐κB Signaling in Colorectal Polyps

Annals of Gastroenterological Surgery, EarlyView.
MiR‐146a‐5p is downregulated in colorectal polyps, leading to IRAK1 upregulation and NF‐κB activation, which promotes M1 macrophage polarization and inflammation. Overexpression of miR‐146a‐5p suppresses IRAK1/NF‐κB signaling, reduces M1 polarization, and alleviates inflammatory responses.
Peng Song, Lianhui Wu, Huabin Qiu, Lei Luo, Jianzhao Qiu, Shuping Xiao, Jincai He   +6 more
wiley   +1 more source