Results 71 to 80 of about 179,113,833 (255)

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Recommendations from the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis

, 2018
Background: In collaboration with United European Gastroenterology, the working group on ‘Harmonizing diagnosis and treatment of chronic pancreatitis across Europe’ (HaPanEU) developed European guidelines for the management of chronic pancreatitis using ...

core   +1 more source

Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days) : Pierrea multi-country, prospective, non-experimental case-control study [PDF]

, 2015
Diarrhoea still accounts for considerable mortality and morbidity worldwide. The highest burden is concentrated in tropical areas where populations lack access to clean water, adequate sanitation and hygiene.
Bratschi, Martin W, von Müller, Lutz, Utzinger, Jürg, Khanal, Basudha, Jacobs, Jan, Bottieau, Emmanuel, Yansouni, Cedric, Thobari, Jarir A., Yap, Peiling, Peeling, Rosanna W., Schneeberger, Pierre H. H., Boelaert, Marleen, Schurmans, Céline, Alirol, Emilie, Bhatta, Nisha K., Yansouni, Cédric P, Yao, Joel A, Landouré, Aly, Thobari, Jarir A, Polman, Katja, Bhattarai, Narayan R, Sacko, Moussa, Traoré, Mamadou S., Yao, Patrick K, Ravinetto, Raffaella, Yansouni, Cédric P., Horié, Ninon S., Murhandarwati, Elsa H., Silué, Kigbafori D., Becker, Sören L, Peeling, Rosanna W, Coulibaly, Jean T., Horié, Ninon S, Murhandarwati, Elsa H, Doumbia, Mama N., Schneeberger, Pierre HH, Mertens, Pascal, Silué, Kigbafori D, Verdonck, Kristien, Meheus, Filip, Yao, Joel A., Coulibaly, Jean T, Bhattarai, Narayan R., Bhatta, Nisha K, Bratschi, Martin W., Mahendradhata, Yodi, Becker, Sören L., van Lieshout, Lisette, Meyanti, Fransiska, Traoré, Mamadou S, N'Goran, Eliézer K., Rijal, Suman, Saye, Rénion, N'Goran, Eliézer K, Yao, Patrick K., Doumbia, Mama N, Burza, Sakib, van Loen, Harry, Chappuis, François   +58 more
core   +1 more source

A Preclinical Multifunctional Capsule Robot with Unified Diagnosis and Targeted Thermal Therapy for Gastrointestinal Diseases

Advanced Science, EarlyView.
A proof‐of‐concept multifunctional capsule robot integrates diagnostic imaging, magnetic navigation, wireless power transfer, and targeted thermotherapy for gastrointestinal applications. Magnetically guided positioning and stable wireless power enable localized thermal ablation, achieving controlled heating and high cell mortality in vitro.
Heng Zhang, Yichong Sun, Xiaoting Zhang, Chi‐Kwan Lee, Zheng Li, Yehui Li, Huarong Chen, Paul D. Mitcheson   +7 more
wiley   +1 more source

Indices of heart rate variability for estimation of adaptive processes and stress resistance in gastroenterology practice (using up-to-date technology of precise-diagnosis)

Gastroenterologìa, 2020
A vast amount of works is devoted to studying the heart rate variability (HRV). The article covers a literature review on modern concepts about heart rate variability as a method for estimation of mechanisms of physiological functions regulation in a ...
Yu.M. Stepanov, E.V. Zyhalo
doaj   +1 more source

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

ASGE guideline for endoscopic full-thickness resection and submucosal tunnel endoscopic resection

VideoGIE, 2019
With the development of reliable endoscopic closure techniques and tools, endoscopic full-thickness resection (EFTR) is emerging as a therapeutic option for the treatment of subepithelial tumors and epithelial neoplasia with significant fibrosis.
Harry R. Aslanian, MD, FASGE, Amrita Sethi, MD, FASGE, Manoop S. Bhutani, MD, FASGE, Adam J. Goodman, MD, FASGE, Kumar Krishnan, MD, David R. Lichtenstein, MD, FASGE, Joshua Melson, MD, FASGE, Udayakumar Navaneethan, MD, Rahul Pannala, MD, MPH, FASGE, Mansour A. Parsi, MD, MPH, FASGE, Allison R. Schulman, MD, MPH, Shelby A. Sullivan, MD, Nirav Thosani, MD, Guru Trikudanathan, MBBS, MD, Arvind J. Trindade, MD, Rabindra R. Watson, MD, John T. Maple, DO, FASGE   +16 more
doaj   +1 more source

Canadian Association of Gastroenterology and the Canadian Digestive Health Foundation: Guidelines on Colon Cancer Screening

, 2004
Colorectal cancer is the third most prevalent cancer affecting both men and women in Canada. Many of these cancers are preventable, and the Canadian Association of Gastroenterology (CAG) and the Canadian Digestive Health Foundation (CDHF) strongly ...
Malcolm Champion, for the Canadian Association of Gastroenterology and the Canadian Digestive Health Foundation committee on colon cancer screening, Alan Cockeram, Richard Hunt, Michael Gould, David Morgan, Desmond Leddin, Dan Sadowski, Susan Natsheh, Young-In Kim, Jonathan Love, Nigel Flook   +11 more
core   +1 more source