Results 231 to 240 of about 335,393 (290)

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

First Report of <i>Haplosporidium edule</i> Infection in the Olive-Green Cockle (<i>Cerastoderma glaucum</i>) from the Northern Adriatic Sea: Expanding Host Range and Geographic Distribution. [PDF]

Pathogens
Vetri A, Basso A, D'Onofrio C, Pretto T, Turolla E, Marcer F, Fiocchi E, Arcangeli G, Cortinovis L, Bilska-Zając E, Menconi V.   +10 more
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Hypoxia inducible factor network reflects kidney disease progression in diabetes and sodium-glucose co-transporters inhibition. [PDF]

Signal Transduct Target Ther
Nair V, Minakawa A, Smith C, Berthier CC, Hartman J, Menon R, Fermin D, Otto EA, Gisch DL, Eadon MT, Jain S, Choi YJ, Pyle L, Eichinger F, Alakwaa FM, Rose MP, Subramanian L, El Saghir J, Beamish JA, Hodgin JB, Brosius FC, Bjornstad P, Nelson PJ, Harder JL, Werner T, Kretzler M, Schaub JA.   +26 more
europepmc   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Sleep Quality and the Influencing Factors in Older Adults Aged 65 Years and Above - 6 PLADs, China, 2025. [PDF]

China CDC Wkly
Gao X, Wang J, Li X, Zheng X, Zhu X, Liu S, Lai J.   +6 more
europepmc   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Non-cancer mortality among firefighters: a meta-analytic review of heart disease, stroke, respiratory disease, liver disease, accidents, and suicide. [PDF]

Front Public Health
Pinheiro PS, Ahn S, Negron S, Pinilla V, Kobetz EN, Caban-Martinez AJ, Lee DJ.   +6 more
europepmc   +1 more source

Continuous Glucose Monitoring and Mortality Risk Among U.S. Veterans Receiving Dialysis With Diabetes. [PDF]

Diabetes Care
Narasaki Y, Kalantar-Zadeh K, Zisman-Ilani Y, Klonoff DC, Kovesdy CP, Li Z, Jin A, Crowley S, M Belcher J, Gee P, Gin GE, Jordan M, You AS, Daza AC, Hanna R, Nguyen DV, Rhee CM.   +16 more
europepmc   +1 more source

Integrating migration into cancer geography: spatial clustering of five digestive cancer burden in China. [PDF]

Front Public Health
Li G, Xue L, Hao S, Du L, Sun H, Zhang Y, Lu Q, Liu M, Wang Y, Jia Y, Feng C, Wang T, Li Q.   +12 more
europepmc   +1 more source