Results 151 to 160 of about 2,879,932 (270)

Effects of Secukinumab on Enthesiophyte and Erosion Progression in Psoriatic Arthritis: A One‐Year Double‐Blind, Randomized, Placebo‐Controlled Trial Using High‐Resolution Peripheral Quantitative Computed Tomography

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to ascertain the effect of secukinumab on erosion and enthesiophyte progression in psoriatic arthritis (PsA) by using high‐resolution peripheral quantitative computed tomography (HR‐pQCT). Methods This was a phase 4, double‐blind, randomized, placebo‐controlled trial.
Yingzhao Jin, Isaac T. Cheng, Ho So, Billy T. Lai, Shirley K. Ying, Kitty Y. Kwok, James Griffith, Vivian Hung, Cheuk‐Chun Szeto, Jack J. Lee, Ling Qin, Lai‐Shan Tam   +11 more
wiley   +1 more source

Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation

Arthritis &Rheumatology, Accepted Article.
Objectives Chondrocyte metabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein post‐translational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK) and its regulator Sirt5 in OA development ...
Huanhuan Liu, Anupama Binoy, Siqi Ren, Thomas C. Martino, Anna E. Miller, Craig R. G. Willis, Shivakumar R. Veerabhadraiah, Joanna Bons, Jacob P. Rose, Birgit Schilling, Michael J. Jurynec, Shouan Zhu   +11 more
wiley   +1 more source

Incidence of major adverse cardiovascular events in patients with rheumatoid arthritis treated with Janus kinase inhibitors compared to biologic disease‐modifying antirheumatic drugs: data from an international collaboration of registries (the "JAK‐pot" study)

Arthritis &Rheumatology, Accepted Article.
Objective To assess the incidence of major adverse cardiovascular events (MACE) in RA patients treated with JAKi, TNF‐inhibitors (TNFi) or biologic Disease‐Modifying Anti‐Rheumatic Drugs with other modes of action (bDMARD‐OMA) in a multi‐country, real‐world population.
Romain Aymon, Denis Mongin, Romain Guemara, Zubeyir Salis, Johan Askling, Denis Choquette, Catalin Codreanu, Daniela Di Giuseppe, Irini Flouri, Doreen Huschek, Kimme L Hyrich, Florenzo Iannone, Tore K Kvien, Burkhard F Leeb, Dan Nordström, Lucia Otero‐Varela, Karel Pavelka, Manuel Pombo‐Suarez, Ana Rodrigues, Ziga Rotar, Prodromos Sidiropoulos, Sella A Provan, Anja Strangfeld, Trokovic Nina, Jakub Zavada, Lianne Kearsley‐Fleet, Delphine S Courvoisier, Axel Finckh, Kim Lauper   +28 more
wiley   +1 more source

Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP‐D10 Improves the Skeletal Phenotypes in Murine Models of Osteomalacia

JBMR Plus, Volume 7, Issue 1, January 2023., 2023
ABSTRACT Hypophosphatasia (HPP), caused by loss‐of‐function mutations in the ALPL gene encoding tissue‐nonspecific alkaline phosphatase (TNAP), is characterized by skeletal and dental hypomineralization that can vary in severity from life‐threatening to milder manifestations only in adulthood.
Flavia Amadeu de Oliveira, Fatma F. Mohamed, Yuka Kinoshita, Sonoko Narisawa, Colin Farquharson, Koichi Miyake, Brian L Foster, Jose Luis Millan   +7 more
wiley   +1 more source

Pain syndrome structure under musculoskeletal system diseases [PDF]

Osteoarthritis and Cartilage, 2015
U. Pryimich, Vladyslav Povoroznyuk
openaire   +2 more sources

Paradoxical Activation of Entheseal Myeloid Cells by JAK1 and TYK2 Inhibitors via IL10 Antagonism

Arthritis &Rheumatology, Accepted Article.
Background JAK inhibition (JAKi) is effective in seronegative spondyloarthropathy (SpA) spectrum disorders, but TYK2 inhibition failed in SpA spectrum ulcerative colitis, and tofacitinib showed minimal benefit in Crohn's Disease, which highlights the complex role for JAK‐STAT signaling in different inflammatory processes. In this study, we investigated
Sami Giryes, Chi Wong, Charlie Bridgewood, Mark Harland, Ala Altaie, Nicole McDermott, Kerem Abacar, Abhay Rao, Almas Khan, Tristan McMillan, Peter Loughenbery, Robert Dunsmuir, Vishal Borse, Tom Macleod, Dennis McGonagle   +14 more
wiley   +1 more source

Longitudinal Change in Bone Density, Geometry, and Estimated Bone Strength in Older Men and Women From The Gambia: Findings From the Gambian Bone and Muscle Aging Study (GamBAS)

Journal of Bone and Mineral Research, Volume 38, Issue 1, Page 48-58, January 2023., 2023
ABSTRACT Musculoskeletal aging in the most resource‐limited countries has not been quantified, and longitudinal data are urgently needed to inform policy. The aim of this prospective study was to describe musculoskeletal aging in Gambian adults. A total of 488 participants were recruited stratified by sex and 5‐year age band (aged 40 years and older ...
Mícheál Ó Breasail, Camille Pearse, Ayse Zengin, Landing Jarjou, Cyrus Cooper, Peter R Ebeling, Ann Prentice, Kate A Ward   +7 more
wiley   +1 more source

Editorial: The immune system and inflammation in musculoskeletal health, aging, and disease

Frontiers in Immunology, 2023
Gurpreet S. Baht, Matthew W. Grol
openaire   +3 more sources

Role of ICAM-1 in the Adhesion of T Cells to Enteric Glia: Perspectives in the Formation of Plexitis in Crohn’s DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: The presence of myenteric plexitis in the proximal resection margins is a predictive factor of early postoperative recurrence in Crohn’s disease.
Julie Pabois, Tony Durand, Catherine Le Berre, Rhiannon T. Filippone, Théo Noël, Emilie Durieu, Céline Bossard, Sarah Bruneau, Malvyne Rolli-Derkinderen, Kulmira Nurgali, Michel Neunlist, Arnaud Bourreille, Isabelle Neveu, Philippe Naveilhan   +13 more
doaj  

Gamifying anatomy outreach: An underexplored opportunity

Anatomical Sciences Education, EarlyView.
Abstract This article explores the underutilized potential of incorporating gamified approaches into anatomy outreach initiatives. While gamification and game‐based learning approaches have been widely adopted in formal educational settings, there is a surprising lack of research on their application for community‐based public engagement with anatomy ...
Mikaela L. Stiver, Aamna Naveed, John Chilton, Siobhan M. Moyes   +3 more
wiley   +1 more source