Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
3D anatomical atlas of the heads of male and female adult Chamaeleo calyptratus
The veiled chameleon is a model organism in reptile development research. Utilizing contrast‐enhanced microCT and deep learning segmentation models, we have generated the first digital atlases of the skull, nervous system, cranial muscles and hyolingual muscles.
Alice Leavey +3 more
wiley +1 more source
Profiling Disease Patterns Using ICD-11 at a University Hospital in Ghana: A Retrospective Analysis of Cross-Sectional Data From 2018 to 2021. [PDF]
Ampah BA +7 more
europepmc +1 more source
Abstract Studies investigating paleopathologies in sauropods remain scarce despite their relative abundance in the fossil record. In this study we report new occurrence of paleopathological features, corresponding to a neoplasm found in a middle caudal vertebra (MCT.R.2120) of an advanced titanosaur from the Presidente Prudente Formation (Bauru Basin ...
Maria Luiza Peres Bertolossi +5 more
wiley +1 more source
Clinical importance of simple muscular fitness tests to predict long-term health conditions: a systematic review and meta-analysis of 94 cohort studies. [PDF]
Marín-Jiménez N +11 more
europepmc +1 more source
Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques [PDF]
Diamond, Michael S +3 more
core +1 more source
Purpose To compare intraoperative findings associated with instability and clinical outcomes after hip arthroscopic femoroacetabular impingement syndrome (FAIS) surgery in patients with normal anteversion (NA) and excessive femoral anteversion (EA). Methods Inclusion criteria were FAIS cases who underwent primary arthroscopic management from January ...
Yohei Matsushita +10 more
wiley +1 more source
Effects of meteorological variability on the burden of musculoskeletal disorders among people aged 55 and above in the United States: a secondary analysis of the Global Burden of Disease Study 2021. [PDF]
Zhou Y, Wang J, Xie Z, Zhang J.
europepmc +1 more source
Purpose To critically evaluate the impact of tranexamic acid (TXA) on hip arthroscopy outcomes, including its effects on bleeding, functional recovery, postoperative pain, complications, intraoperative visualization, and surgical efficiency. Methods A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic ...
Paul B. Walker +6 more
wiley +1 more source

