Results 1 to 10 of about 261,948 (310)

Subassemblies and Asymmetry in Assembly of Herpes Simplex Virus Procapsid

mBio, 2015
The herpes simplex virus 1 (HSV-1) capsid is a massive particle (~200 MDa; 1,250-Å diameter) with T=16 icosahedral symmetry. It initially assembles as a procapsid with ~4,000 protein subunits of 11 different kinds.
Anastasia A. Aksyuk, William W. Newcomb, Naiqian Cheng, Dennis C. Winkler, Juan Fontana, J. Bernard Heymann, Alasdair C. Steven   +6 more
doaj   +1 more source

Distribution characteristics of self-reported diseases and occupational injuries among workers in manufacturing enterprises

环境与职业医学
BackgroundDiseases severely affect the efficiency of workers. Comorbidity refers to the coexistence of two or more chronic diseases or health problems in the same individual.
Lin ZHANG, Zhi’an LI, Yishuo GU, Juan QIAN, Chunhua LU, Jianjian QIAO, Yong QIAN, Zeyun YANG, Xiaojun ZHU   +8 more
doaj   +1 more source

P1414: MARROW ADIPOCYTE-ENRICHED NICHE HOSTS AND INFLUENCES A FRACTION OF HEMATOPOIETIC PROGENITORS IN ADULT HIP BONE

HemaSphere, 2022
D. Trivanovic, K. Horas, B. Schlierf, M. Rudert, M. Herrmann   +4 more
doaj   +1 more source

[Musculoskeletal diseases. A review of musculoskeletal diseases and environment].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1989
The article discusses the remarkably high prevalence of occupationally induced muscle pain and musculoskeletal diseases. The causes of this group of pain/disorders are complex. The increasing economic consequences, and the problems, call for research on practical prophylaxis.
openaire   +1 more source

Genome-wide profiling of circulating microRNAs in adolescent idiopathic scoliosis and their relation to spinal deformity severity, and disease pathophysiology

Scientific Reports
Adolescent Idiopathic Scoliosis (AIS) is the most common orthopedic condition requiring surgery, affecting 4% of adolescents. There is currently no proven method or prognostic test to identify symptomatic patients at risk of developing severe scoliosis ...
Nasrin Khatami, Iurie Caraus, Mahamuda Rahaman, Evguenia Nepotchatykh, Mohamed Elbakry, Wesam Elremaly, Anita Franco, Marie Beauséjour, Anne-Marie Laberge, Stefan Parent, Hubert Labelle, Carl-Éric Aubin, Jean Lachaine, Alain Moreau   +13 more
doaj   +1 more source

The primary role of radiological imaging in the diagnosis of rare musculoskeletal diseases. Emphasis on ultrasound

Journal of Ultrasonography, 2019
Objective: In July 2017 a multidisciplinary clinical Center specialized in rare diseases was activated. A rare disease can involve the musculoskeletal system. A multimodality musculoskeletal imaging approach allows for a rapid diagnosis.
Rossi Federica, Martinoli Carlo, Murialdo Giovanni, Schenone Angelo, Grandis Marina, Ferone Diego, Tagliafico Alberto Stefano   +6 more
doaj   +1 more source

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

eLife, 2016
The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remain uncertain.
Alejandro Villarino, Arian Laurence, Gertraud W Robinson, Michael Bonelli, Barbara Dema, Behdad Afzali, Han-Yu Shih, Hong-Wei Sun, Stephen R Brooks, Lothar Hennighausen, Yuka Kanno, John J O'Shea   +11 more
doaj   +1 more source

SMPDL3B a novel biomarker and therapeutic target in myalgic encephalomyelitis

Journal of Translational Medicine
Background Sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B) is emerging as a potential biomarker and therapeutic target in myalgic encephalomyelitis (ME), a complex multisystem disorder characterized by immune dysfunction, metabolic disturbances ...
Bita Rostami-Afshari, Wesam Elremaly, Anita Franco, Mohamed Elbakry, Marie-Yvonne Akoume, Ines Boufaied, Atefeh Moezzi, Corinne Leveau, Pierre Rompré, Christian Godbout, Olav Mella, Øystein Fluge, Alain Moreau   +12 more
doaj   +1 more source

The Role of Nuclear and Mitochondrial DNA in Myalgic Encephalomyelitis: Molecular Insights into Susceptibility and Dysfunction

DNA
Myalgic Encephalomyelitis (ME), also known as chronic fatigue syndrome (CFS), is a debilitating and heterogeneous disorder marked by persistent fatigue, post-exertional malaise, cognitive impairment, and multisystem dysfunction.
Wesam Elremaly, Mohamed Elbakry, Yasaman Vahdani, Anita Franco, Alain Moreau   +4 more
doaj   +1 more source

Biphasic control of the B cell transcriptome by mTORC1 and GSK3

Cell Reports
Summary: A central question in immune regulation is how cells coordinate transcriptional responses to environmental cues. It remains unclear whether transcriptional regulation is controlled by isolated mechanism or integrated regulatory programs.
Jens Kalchschmidt, Tomoya Kanno, Solji Park, Wendy D. Dubois, Yongbing Zhao, Pawel Trzaskoma, Craig J. Thomas, Louis M. Staudt, John J. O’Shea, Seolkyoung Jung, Rafael Casellas   +10 more
doaj   +1 more source