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The Role of Extracellular Vesicles in Musculoskeletal Diseases [PDF]

Journal of Extracellular Vesicles
Extracellular Vesicles (EVs), nanoscale membrane‐bound cell‐released structures, are vital for intercellular communication and material transport. Their role in musculoskeletal health and diseases has recently drawn significant attention.
Peng‐jie Fu, Yan Luo, Sheng‐yuan Zheng, Zhe‐ru Ma, Wen‐feng Xiao, Hui Li, Yu‐sheng Li   +6 more
doaj   +2 more sources

Degenerative joint disease induced by repeated intra-articular injections of monosodium urate crystals in rats as investigated by translational imaging

Scientific Reports, 2022
The objective of this work was to assess the consequences of repeated intra-articular injection of monosodium urate (MSU) crystals with inflammasome priming by lipopolysaccharide (LPS) in order to simulate recurrent bouts of gout in rats.
Nathalie Accart, Janet Dawson, Michael Obrecht, Christian Lambert, Manuela Flueckiger, Julie Kreider, Shinji Hatakeyama, Peter J. Richards, Nicolau Beckmann   +8 more
doaj   +1 more source

Challenges documenting racial disparities in Merkel cell carcinoma

Cancer Biology & Therapy, 2022
Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer that predominantly impacts White patients. Overall incidence and the proportion of minority patients with MCC are both rising.
Mackenzie R. Martin, Noreen Mohsin, Serena Vilasi, Danielle Reed, Isaac Brownell   +4 more
doaj   +1 more source

Lifestyle factors predict gout outcomes: Results from the NOR-Gout longitudinal 2-year treat-to-target study

RMD Open, 2023
Objective Gout is associated with lifestyle, body mass index (BMI) and comorbidities, including dyslipidaemia. We studied how in actively treated patients, anthropometric measures and lipid levels changed over 2 years and whether they predicted gout ...
Tore K Kvien, Joseph Sexton, Till Uhlig, Espen A Haavardsholm, Hilde Berner Hammer, Lars Fridtjof Karoliussen   +5 more
doaj   +1 more source

Willingness, perceived facilitators and barriers to use remote care among healthcare professionals – a cross-sectional study

BMC Health Services Research, 2023
Background Remote care has the potential of improving access to timely care for people with inflammatory joint diseases (IJD), but there is limited knowledge on how this approach is regarded by healthcare professionals (HCP).
Emil Eirik Kvernberg Thomassen, Inger Jorid Berg, Eirik Klami Kristianslund, Anne Therese Tveter, Nina Østerås   +4 more
doaj   +1 more source

Effect of a mHealth exercise intervention compared with supervised exercise therapy in osteoarthritis management: protocol of the DigiOA trial

BMJ Open, 2022
Introduction Soaring prevalence of hip and knee osteoarthritis (OA) inflicts high costs on the healthcare system. A further rise in the OA incidence is expected, generating increased demand of care potentially challenging accessibility and threatening to
Nina Østerås, Anne Therese Tveter, Lars Martinsen, Tuva Moseng   +3 more
doaj   +1 more source

Degenerative musculoskeletal disease [PDF]

Annals of the Rheumatic Diseases, 2004
Is the demographic transition impacting on the perception of degenerative musculoskeletal disease? The world is witnessing an unprecedented, irremediable, and longlasting aging process.1,2 Table 1 provides population decennial growth rates by 10 year age groups and shows marked differences across age groups.
Ethgen, Olivier, Reginster, Jean-Yves
openaire   +3 more sources

Musculoskeletal diseases--tendon [PDF]

British Medical Bulletin, 2011
Tendons establish specific connections between muscles and the skeleton by transferring contraction forces from skeletal muscle to bone thereby allowing body movement. Tendon physiology and pathology are heavily dependent on mechanical stimuli. Tendon injuries clinically represent a serious and still unresolved problem since damaged tendon tissues heal
Tomoya, Sakabe, Takao, Sakai
openaire   +2 more sources

Circulating microRNA expression signatures accurately discriminate myalgic encephalomyelitis from fibromyalgia and comorbid conditions

Scientific Reports, 2023
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and fibromyalgia (FM) are two chronic complex diseases with overlapping symptoms affecting multiple systems and organs over time.
Evguenia Nepotchatykh, Iurie Caraus, Wesam Elremaly, Corinne Leveau, Mohamed Elbakry, Christian Godbout, Bita Rostami-Afshari, Diana Petre, Nasrin Khatami, Anita Franco, Alain Moreau   +10 more
doaj   +1 more source

Associations between cardiovascular risk factors, disease activity and cardiorespiratory fitness in patients with inflammatory joint disease: a cross-sectional analysis

BMC Sports Science, Medicine and Rehabilitation, 2023
Background Inflammatory joint diseases (IJD) are accompanied by an increased risk of cardiovascular disease (CVD). Cardiorespiratory fitness (CRF) is a modifiable CVD risk factor and low levels of CRF associate with an elevated CVD risk. This study aimed
Kristine Røren Nordén, Anne Grete Semb, Hanne Dagfinrud, Jonny Hisdal, Sigrid Ødegård, Joseph Sexton, Camilla Fongen, Jon Skandsen, Thalita Blanck, George S. Metsios, Anne Therese Tveter   +10 more
doaj   +1 more source