Results 41 to 50 of about 2,606,690 (298)

Protocol for the MERINO study: A randomized placebo-controlled trial assessing the efficacy, safety, and cost-effectiveness of methotrexate in people with erosive hand osteoarthritis

Osteoarthritis and Cartilage Open
Objective: Previous studies on the efficacy of methotrexate in people with hand osteoarthritis (OA) have shown conflicting results. The MERINO trial aims to investigate the efficacy and safety of methotrexate in people with painful inflammatory erosive ...
Alexander Mathiessen, Line Gaundal, Joseph Sexton, Dag Sjølie, Pernille Steen Pettersen, Barbara Slatkowsky-Christensen, Ida Kristin Haugen   +6 more
doaj   +1 more source

Testing the construct validity of a health transition question using vignette-guided patient ratings of health

Health and Quality of Life Outcomes, 2018
Background A single-item transition question is often used to assess improvement or worsening in health, but its validity has not been tested extensively.
Michael M. Ward, Jinxiang Hu, Lori C. Guthrie, Maria Alba   +3 more
doaj   +1 more source

Mechanoepigenetics in musculoskeletal disease

Osteoarthritis and Cartilage
This review explores the intricate interplay between genetic variants, mechanical forces, and the epigenetic landscape (defined as 'mechanoepigenetics'), particularly in the context of musculoskeletal (MSK) diseases such as osteoarthritis. Whilst our understanding of Mendelian monogenic disease has progressed with exome sequencing and the generation of
Coveney, Clarissa R., Capellini, Terence D.   +1 more
openaire   +3 more sources

Organisational downsizing and musculoskeletal problems in employees: a prospective study [PDF]

, 2001
Objectives: To study the association between organisational downsizing and subsequent musculoskeletal problems in employees and to determine the association with changes in psychosocial and behavioural risk factors.
Vahtera, J., Ferrie, J.E., Pentti, J., Hemingway, H., Kivimäki, M.   +4 more
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From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Musculoskeletal Diseases: From Molecular Basis to Therapy (Volume II). [PDF]

Biomedicines
Musculoskeletal diseases (MSDs) are among the leading causes of disability worldwide, placing a significant burden on healthcare systems and reducing patients’ quality of life [...
Belluzzi E, Pozzuoli A, Ruggieri P.
europepmc   +2 more sources

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

IMAGING METHODS IN MUSCULOSKELETAL SYSTEM PAIN

, 2022
Musculoskeletal system pain frequency increases with the aging population. Taking a detailed history and physical examination are the most important things for a correct diagnosis. Imaging should be considered as a tool to confirm the diagnosis. A number
Akçiçek, Mehmet
core   +1 more source

Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression

Scientific Reports, 2017
C1q collagen-like region (CLR) engaging and activating the LAIR-1 inhibitory immunoreceptor represents a non-complement mechanism for maintaining immune quiescence.
Myoungsun Son, Betty Diamond, Bruce T. Volpe, Cynthia B. Aranow, Meggan C. Mackay, Frances Santiago-Schwarz   +5 more
doaj   +1 more source

Arthritis and other musculoskeletal conditions across the life stages [PDF]

, 2014
Arthritis and other musculoskeletal conditions affect an estimated 6.1 million Australians across all ages, this report finds. Summary Arthritis and other musculoskeletal conditions are common, affecting an estimated 6.1 million Australians (28% of the

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