Results 41 to 50 of about 2,495,332 (299)
Osteoarthritis and Cartilage OpenObjective: Previous studies on the efficacy of methotrexate in people with hand osteoarthritis (OA) have shown conflicting results. The MERINO trial aims to investigate the efficacy and safety of methotrexate in people with painful inflammatory erosive ...
Alexander Mathiessen +6 more
doaj +1 more source
Health and Quality of Life Outcomes, 2018 Background A single-item transition question is often used to assess improvement or worsening in health, but its validity has not been tested extensively.
Michael M. Ward +3 more
doaj +1 more source
Mechanoepigenetics in musculoskeletal disease
Osteoarthritis and CartilageThis review explores the intricate interplay between genetic variants, mechanical forces, and the epigenetic landscape (defined as 'mechanoepigenetics'), particularly in the context of musculoskeletal (MSK) diseases such as osteoarthritis. Whilst our understanding of Mendelian monogenic disease has progressed with exome sequencing and the generation of
Coveney, Clarissa R. +1 more
openaire +3 more sources
Arthritis Care &Research, EarlyView.Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel +6 more
wiley +1 more source
"The proceedings of a conference on the development of a national strategy for occupational musculoskeletal injuries were summarized. Specific topics discussed included the scope of the national program, major federal government initiatives, the passage ...
core +1 more source
Arthritis Care &Research, EarlyView.Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer +4 more
wiley +1 more source
Scientific Reports, 2017 C1q collagen-like region (CLR) engaging and activating the LAIR-1 inhibitory immunoreceptor represents a non-complement mechanism for maintaining immune quiescence.
Myoungsun Son +5 more
doaj +1 more source
Recommendations for exercise adherence measures in musculoskeletal settings : a systematic review and consensus meeting (protocol) [PDF]
, 2014 Background: Exercise programmes are frequently advocated for the management of musculoskeletal disorders; however, adherence is an important pre-requisite for their success.
Potia, Tanzila A. +12 more
core +2 more sources
Arthritis Care &Research, EarlyView.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source
An upper limb musculoskeletal model using bond graphs for rotorcraft-pilot couplings analysis [PDF]
, 2014 Under certain flight conditions, a rotorcraft fuselage motions and vibrations might interact with its pilot voluntary and involuntary actions leading to potentially dangerous dynamic instabilities known as rotorcraft-pilot couplings (RPCs).
GOMAND, Julien +3 more
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