Results 41 to 50 of about 261,948 (310)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Incidence and prevalence of complaints of the neck and upper extremity in general practice

, 2005
OBJECTIVE: To study the incidence and prevalence of neck and upper extremity musculoskeletal complaints in Dutch general practice. METHODS: Data were obtained from the second Dutch national survey of general practice.
Bot, Sandra D.M., Bouter, L. M., Schellevis, F. G., Waal, J.M. van der, Schellevis, F.G., Dekker, J., Van Der Waal, J. M., Bouter, L.M.; id_orcid, Terwee, C. E., Terwee, C.B., Windt, D.A.W.M. van der, Windt - Mens, D.A.W.M. van der, Bouter, L.M., Bot, S.D.M., van der Windt-Mens, D.A.W.M., van der Waal, J.M., Van Der Windt, D. A.W.M.   +16 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

How to score the wrist joint by ultrasound: exploration of the most sensitive joint assessment during follow-up of early or established rheumatoid arthritis

Arthritis Research & Therapy
Background Wrist inflammation is common in patients with rheumatoid arthritis (RA), and thus there is room for debate on which joints to include in an ultrasound-based scoring of wrist synovitis in RA.
Yusuke Yoshida, Hilde Berner Hammer, Joseph Sexton, Lena Nordberg, Anna-Birgitte Aga, Lene Terslev, Siri Lillegraven, Espen A. Haarvardsholm   +7 more
doaj   +1 more source

Remote personalised exercise in axial spondyloarthritis: the SPARK trial – protocol for a 6-month randomised controlled trial

BMJ Open
Introduction Current international guidelines recommend exercise as a first-line treatment of axial spondyloarthritis (SpA). However, there is no consensus on the mode and volume required to effectively reduce disease activity.
Loreto Carmona, Siri Lillegraven, Hanne Dagfinrud, Silje Halvorsen Sveaas, Inger Jorid Berg, Eirik Klami Kristianslund, Nina Østerås, Sella Aarrestad Provan, Tanja Schjødt Jørgensen, Joe Sexton, Kristine Røren Nordén, Camilla Fongen, Birgitte Nellemann   +12 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Protocol for the MERINO study: A randomized placebo-controlled trial assessing the efficacy, safety, and cost-effectiveness of methotrexate in people with erosive hand osteoarthritis

Osteoarthritis and Cartilage Open
Objective: Previous studies on the efficacy of methotrexate in people with hand osteoarthritis (OA) have shown conflicting results. The MERINO trial aims to investigate the efficacy and safety of methotrexate in people with painful inflammatory erosive ...
Alexander Mathiessen, Line Gaundal, Joseph Sexton, Dag Sjølie, Pernille Steen Pettersen, Barbara Slatkowsky-Christensen, Ida Kristin Haugen   +6 more
doaj   +1 more source

Testing the construct validity of a health transition question using vignette-guided patient ratings of health

Health and Quality of Life Outcomes, 2018
Background A single-item transition question is often used to assess improvement or worsening in health, but its validity has not been tested extensively.
Michael M. Ward, Jinxiang Hu, Lori C. Guthrie, Maria Alba   +3 more
doaj   +1 more source

1991 conference summary [PDF]

"The proceedings of a conference on the development of a national strategy for occupational musculoskeletal injuries were summarized. Specific topics discussed included the scope of the national program, major federal government initiatives, the passage ...

core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source