Results 191 to 200 of about 205,118 (263)

Adverse events in bedaquiline‐ and pretomanid‐based regimens for drug‐resistant tuberculosis from trial, implementation and pharmacovigilance studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract The availability of safety data, particularly concerning adverse events (AEs) associated with the new shorter regimen for drug‐resistant tuberculosis (TB) containing a bedaquiline–pretomanid‐based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by ...
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin‐Gun Cho, Jan‐Willem C. Alffenaar   +4 more
wiley   +1 more source

SPINAL DISORDERS IN PROFESSIONAL ESPORTS ATHLETES: PROTOCOL FOR A SYSTEMATIC REVIEW. [PDF]

Acta Ortop Bras
Miachiro NY, de Menezes MD, Pontes MDS, Herrero CFPDS.   +3 more
europepmc   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

British Journal of Clinical Pharmacology, EarlyView.
Aim Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...
Alexandra A. J. Sillé, Juliette A. van den Noort, Iva Lelios, Diana R. Pereira, Marzia A. Scelsi, Erica S. Klaassen, Philipp Schoenenberger, Naomi B. Klarenbeek, Pierre‐Eric Juif, Pascal Espie, Manon A. A. Jansen, Matthijs Moerland, Richard W. D. Welford   +12 more
wiley   +1 more source

Adverse events associated with statin co-use in breast cancer patients: a disproportionality analysis based on the FDA Adverse Event Reporting System. [PDF]

Ther Adv Drug Saf
Zhang Y, Peng W, Yang W, Gao Y, Fan Y, Guo Q.   +5 more
europepmc   +1 more source

The pathological Huntingtin CAG triplet expansion differentially affects the diagnosis of systemic and organ-specific autoimmune diseases. [PDF]

Front Immunol
Heyd M, Landwehrmeyer GB, Lewerenz J.
europepmc   +1 more source

Quantifying dynamic muscle lengths and moment arms of musculoskeletal joints using FEBio studio: A demonstration in the glenohumeral joint. [PDF]

J Biomech
Hardy BJ, Maas SA, Percin B, Foreman KB, King PL, Henninger HB.   +5 more
europepmc   +1 more source

Acute SARS-CoV-2 viral load and systemic inflammation are associated with neuropsychiatric and musculoskeletal symptoms in long COVID. [PDF]

PLoS One
Abbas U, Laghari RN, Ahmed I, Musawwir UA, Riaz H, Anwar K, Hussain N, Mubeen M, Khan M, Khalid MU, Ashraf S.   +10 more
europepmc   +1 more source

Osteoarthritis and dementia: contrasting disorders driven by mutual pathways of autophagy, mTOR, GLP-1, AMPK, Wnt, and WISP1. [PDF]

Expert Rev Clin Pharmacol
Maiese K.
europepmc   +1 more source

Influence of k-wire placement on impact mechanics and bone fracture in a rabbit model of cartilage injury. [PDF]

PLoS One
Noori-Dokht H, Dilley J, Seetharam A, Sankar U, Natoli RM, McKinley TO, Wagner DR.   +6 more
europepmc   +1 more source