Results 81 to 90 of about 205,118 (263)

The emerging role of Piezo1 in the musculoskeletal system and disease

Theranostics
Piezo1, a mechanosensitive ion channel, has emerged as a key player in translating mechanical stimuli into biological signaling. Its involvement extends beyond physiological and pathological processes such as lymphatic vessel development, axon growth, vascular development, immunoregulation, and blood pressure regulation.
Lei, Lei, Wen, Zhenkang, Cao, Mingde, Zhang, Haozhi, Ling, Samuel Ka-Kin, Fu, Bruma Sai-Chuen, Qin, Ling, Xu, Jiankun, Yung, Patrick Shu-Hang   +8 more
openaire   +2 more sources

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Distribution characteristics of self-reported diseases and occupational injuries among workers in manufacturing enterprises

环境与职业医学
BackgroundDiseases severely affect the efficiency of workers. Comorbidity refers to the coexistence of two or more chronic diseases or health problems in the same individual.
Lin ZHANG, Zhi’an LI, Yishuo GU, Juan QIAN, Chunhua LU, Jianjian QIAO, Yong QIAN, Zeyun YANG, Xiaojun ZHU   +8 more
doaj   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Synthetic biomaterials based on hydroxyapatite and tricalcium phosphate: analysis of current clinical trials

Гений oртопедии
Introduction To date, a wide variety of synthetic materials, including metals, polymers and ceramics, have been proposed and used as a substitute for bone grafts in the field of traumatology/orthopedics, neurosurgery and oral and maxillofacial surgery (
Ural F. Mukhametov, Denis S. Ivliev, Ilgiz F. Gareev, Sergey V. Lyulin, Dmitry Yu. Borzunov   +4 more
doaj   +1 more source

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

Study the role of intercellular mediators in the metabolism of connected tissue in children with cardiomyopathy and osteopeny = Вивчення ролі міжклітинних медіаторів у метаболізмі сполучної тканини у дітей з кардіопатією та остеопенією

Journal of Education, Health and Sport, 2016
Pavlov S. B., Pavlova G. B. Study the role of intercellular mediators in the metabolism of connected tissue in children with cardiomyopathy and osteopeny = Вивчення ролі міжклітинних медіаторів у метаболізмі сполучної тканини у дітей з кардіопатією та ...
S. B. Pavlov, G. B. Pavlova
doaj  

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

The Role of Extracellular Vesicles in Musculoskeletal Diseases

Journal of Extracellular Vesicles
Extracellular Vesicles (EVs), nanoscale membrane‐bound cell‐released structures, are vital for intercellular communication and material transport. Their role in musculoskeletal health and diseases has recently drawn significant attention.
Peng‐jie Fu, Yan Luo, Sheng‐yuan Zheng, Zhe‐ru Ma, Wen‐feng Xiao, Hui Li, Yu‐sheng Li   +6 more
doaj   +1 more source

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, EarlyView.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source