Results 91 to 100 of about 1,574,428 (338)

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Exercise for endurance and strength:Always separate? [PDF]

, 2019
Physical training can be classified into three main types: endurance, resistance, and patterned movements. The first two of them have a significant impact on muscle phenotype and metabolism while patterned movement exercises concern changes in a motor ...
Clark, Cain C.T., Gronek, Piotr, Kryściak, Jakub, Stroińska, Weronika   +3 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Cache valley virus in a patient diagnosed with aseptic meningitis [PDF]

, 2013
Cache Valley virus was initially isolated from mosquitoes and had been linked to central nervous system-associated diseases. A case of Cache Valley virus infection is described.
Hull, Rene, Menegus, Marilyn A, Nguyen, Nang L, Shelly, Mark A, St. George, Kirsten, Wang, David, Wong, Susan J, Wu, Guang, Zhao, Guoyan   +8 more
core   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Cognitive impairment and mental disorders in patients with focal muscular dystonia

Неврология, нейропсихиатрия, психосоматика, 2019
Non-motor manifestations in focal muscular dystonia (FMD) have been little studied. Objective: to analyze the characteristics of cognitive impairment (CI) and mental disorders (MDs) in FMD. Patients and methods.
V. A. Tolmacheva, D. A. Grishina, D. V. Romanov   +2 more
doaj   +1 more source

Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system. [PDF]

, 2021
Leticia Laura Niborski, Mariana Potenza, Renato G.S. Chirivi, Leandro Simonetti, Micaela S. Ossowski, Vanina Grippo, María May, Daniela I. Staquicini, Adriana Parodi‐Talice, Carlos Robello, Marcelo A. Comini, G. Alonso, Jos Raats, Karina A. Gómez   +13 more
openalex   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Serum amyloid A primes microglia for ATP-dependent interleukin-1\u3b2 release [PDF]

, 2018
Acute-phase response is a systemic reaction to environmental/inflammatory insults and involves production of acute-phase proteins, including serum amyloid A (SAA).
A Basu, A Franceschini, AA Culbert, AJ Sharp, AL Giuliani, AM Van Dam, B Sperlágh, C Gabay, C Marinelli, C Solà, C Volonté, CA Dinarello, CM Uhlar, D Ferrari, D Kim, DL Thiele, E Gruys, E Nishida, E Venereau, G Guillemin, G Ristori, H Yokote, I Hardardóttir, I Kushner, I Rajkovic, J Saura, JA Sloane, JS Liang, JT Guo, K Chang, K Niemi, K Selmaj, L Facci, L Facci, L Peferoen, L Probert, L Sun, L Yao, Laura Facci, LK Parvathenani, M Barbierato, M Barbierato, M Casula, M Connolly, M De Buck, M Idzko, M Li, M Sanz, Massimo Barbierato, ME Hamby, MK McCoy, Morena Zusso, MS Kindy, MT Heneka, N Chauvet, N Cheng, P Honore, Pietro Giusti, R Ebert, RA Dal Canto, RJ Rodrigues, S Kim, S Sandri, S Tanaka, SD Skaper, SD Skaper, SD Skaper, SJ Crocker, SJ Hewett, SL Passey, SM Allan, Stephen D. Skaper, SY Seong, T Kawamoto, T Miida, T Tamamoto, TF Chung, TH Holm, XQ Li, Y Kumon, Y Wang, Y Yu, YR Ji   +82 more
core   +2 more sources