Results 71 to 80 of about 246,068 (262)
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Enteric synucleinopathy: real entity or only a trendy concept?
Free Neuropathology, 2020 An accumulating body of literature has emerged in the past 25 years to show that Parkinson’s disease (PD) is not only a disorder of the brain but also of the gastrointestinal tract and more generally of the gut-brain axis. Gastrointestinal symptoms occur
Adrien de Guilhem de Lataillade +4 more
doaj +1 more source
MicroRNA and Diseases of the Nervous System [PDF]
Neurosurgery, 2011 The recent discovery of microRNAs (miRNAs) has caused the traditional central dogma of molecular biology to be rewritten. miRNAs are small, noncoding pieces of ribonucleic acid that exert control over gene expression at the posttranscriptional level. They appear to play important roles in the normal development and functioning of the nervous system and
openaire +2 more sources
Treatment update for autoimmune/immune-mediated central nervous system diseases
Autoimmune/immune-mediated central nervous system (CNS) diseases are chronic, inflammatory, autoimmune diseases, such as multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and autoimmune encephalitis (AE).
Wan Fu +5 more
core +1 more source
, 2014 The compound NVP-BEZ235 (1) is a potent inhibitor of human phospoinositide-3-kinases (PI3Ks) and mammalian target of rapamycin (mTOR) that also showed high inhibitory potency against T. brucei cultures. With an eye towards using 1 as a starting point for
Pollastri, Michael P +10 more
core +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
The enteric nervous system in physiological and pathological conditions
The enteric nervous system is a specific part of the autonomic nervous system, whose role is mainly concerned with ensuring the proper functioning of the gastrointestinal tract.
Tadeusz Kuder +2 more
core +1 more source
Imaging of parasitic diseases of the central nervous system
, 2008 Infections of the central nervous system (CNS), especially parasitic infections, have increased in the last decade secondary to the acquired immunodeficiency syndrome (AIDS) epidemic, immunosuppressive therapy used in treatment of cancer, and in organ ...
Hourani R.G., Tamraz J.C.
core +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source