Results 91 to 100 of about 1,619,548 (347)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Clinical application of sialic acid (II) Sialic acid contents in cerebro-spinal fluid of patients suffering from the disease of the central nervous system [PDF]

, 1959
It is well known that human serum contains some sialic acid and its contents increase markedly in the blood serum of the patients bearing malignant tumors.
Kanbayashi, Tsuneo, Kawakami, Hiroshi, Saito, Kunio, Yamaguchi, Michiya   +3 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Diseases of the Nervous System [PDF]

Annual Review of Medicine, 1957
R A, FISHMAN, H H, MERRITT
openaire   +2 more sources

Prion Disease and the Innate Immune System [PDF]

, 2012
Prion diseases or transmissible spongiform encephalopathies are a unique category of infectious protein-misfolding neurodegenerative disorders. Hypothesized to be caused by misfolding of the cellular prion protein these disorders possess an infectious ...
Akira, Ansel, Aucouturier, Baker, Baker, Baker, Barry Bradford, Bartz, Beaulieu, Beekes, Bergtold, Bessen, Blanquet-Grossard, Bruce, Bueler, Burwinkel, Chesebro, Colten, Colten, Cordier-Dirikoc, Cordier-Dirikoc, Cunningham, de Almeida, Dieu, Erblich, Flores-Langarica, Ford, Fraser, Fraser, Fritz, Fu, Gilch, Glaysher, Hamilton, Heppner, Hosszu, Houston, Hunter, Jonjić, Kim, Kimberlin, Kimberlin, Klein, Klein, Kopacek, Kujala, Le, Le, Levavasseur, Li, Liu, Loeuillet, Lu, Luhr, Luhr, Lunnon, Mabbott, Mabbott, Manson, Marella, Marijanovic, Martinez del Hoyo, Mathiason, McCulloch, McCutcheon, Miragliotta, Mitchell, Mohan, Mok, Moore, Neil Mabbott, Oldstone, Opalinska, Paquet, Parkin, Piercey Åkesson, Prinz, Prinz, Prinz, Prusiner, Raymond, Raymond, Raymond, Rescigno, Riemer, Riemer, Riemer, Robertson, Rosicarelli, Rybner, Rybner-Barnier, Saba, Sassa, Schwaeble, Sein, Sethi, Shanas, Silver, Teh, Thackray, Uraki, Uraki, Veerhuis, Walsh, Wang, Wathne, Williams, Xiang, Yadavalli, Yanamadala, Zabel   +110 more
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Role of ICAM-1 in the Adhesion of T Cells to Enteric Glia: Perspectives in the Formation of Plexitis in Crohn’s DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: The presence of myenteric plexitis in the proximal resection margins is a predictive factor of early postoperative recurrence in Crohn’s disease.
Julie Pabois, Tony Durand, Catherine Le Berre, Rhiannon T. Filippone, Théo Noël, Emilie Durieu, Céline Bossard, Sarah Bruneau, Malvyne Rolli-Derkinderen, Kulmira Nurgali, Michel Neunlist, Arnaud Bourreille, Isabelle Neveu, Philippe Naveilhan   +13 more
doaj   +1 more source

Facet joint osteoarthritis as a cause of chronic low back pain

Неврология, нейропсихиатрия, психосоматика, 2019
Chronic nonspecific low back pain (LBP) is the most common cause of disability and a lower quality of life in modern society.Objective: to discuss the feasibility of identifying the causes of chronic nonspecific LBP and in the case of detection of damage
D. O. Rozhkov, O. E. Zinovyeva, A. N. Barinov, A. M. Nosovsky   +3 more
doaj   +1 more source

Contactin-2/TAG-1, active on the front line for three decades [PDF]

, 2017
Contactin-2/transiently expressed axonal surface glycoprotein-1 (TAG-1) is a cell adhesion molecule belonging to the immunoglobulin superfamily (IgSF).
Masuda Tomoyuki, 増田 知之
core   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source