Results 61 to 70 of about 246,068 (262)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Drp1-CoQ10-Coa6-ETC axis represents a therapeutic potential for working memory impairment caused by neuronal mitochondrial dysfunction

Translational Neurodegeneration
Background Coenzyme Q10 (CoQ10) is a key mitochondrial electron carrier and a widely used dietary supplement with potential neurological benefits. However, the mechanisms underlying its effect in ameliorating memory deficits caused by cerebellar injury ...
Jingjing Tie, Shujiao Li, Xin Huang, Keke Ren, Ziwei Ni, Xiaodong Li, Changlei Zhu, Hui Liu, Feifei Wu, Yanling Yang, Yayun Wang   +10 more
doaj   +1 more source

Large-Scale Multi-Omic Approaches and Atlas-Based Profiling for Cellular, Molecular, and Functional Specificity, Heterogeneity, and Diversity in the Endocannabinoid System

, 2023
The endocannabinoid system (ECS) is a widely-recognized lipid messenger system involved in many aspects of our our lives in health and diseases [...
Masako Isokawa, Jun Aoki
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

New Application of 123I-Iodoamphetamine SPECT for the Diagnosis of Primary Central Nervous System Lymphoma

, 2014
123I-iodoamphetamine (IMP) single photon emission computed tomography (SPECT) is used to evaluate the cerebral blood flow (CBF) in patients with either cerebrovascular or neurodegenerative diseases [3 6].
SHIBATA Yasushi, Yasushi Shibata
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Hydrotherapy in nervous system diseases

, 2019
SUMMARY Hydrotherapy is one method used in the rehabilitation treatment of various diseases, including diseases of the nervous system with a positive result. It is used in many exercise programs.
Joanna Iłżecka, Iłżecka, Joanna
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Dermatological manifestations of nervous system diseases

, 2016
It is a generally accepted principle that the skin is a mirror of human health. Also neurological conditions may be accompanied by characteristic skin changes of significant diagnostic value.
Piotr Trojanowski, Monika Łagowska-Lenard, Rafał Lenard, Marcin Wdowiak, Urszula I. Zielińska, Michał Rutkowski, Radosław Rola, Agata Smoleń, Bartłomiej Tyzo   +8 more
core   +1 more source

The peripheral nervous system and the pathogenesis of prion diseases. [PDF]

, 2004
Prion diseases are inevitably fatal neurodegenerative conditions which affect humans and a wide variety of animals. Unlike other protein aggregation diseases such as Alzheimer's, Parkinson's, and polyglutamine repeat diseases, prion diseases are unique ...
Giger, O, Glatzel, M, Braun, N, Aguzzi, A; https://orcid.org/   +3 more
core   +1 more source