Results 71 to 80 of about 1,195,331 (367)

MIND-BODY RESPONSE AND NEUROPHYSIOLOGICAL CHANGES DURING STRESS AND MEDITATION: CENTRAL ROLE OF HOMEOSTASIS [PDF]

, 2014
Stress profoundly impacts quality of life and may lead to various diseases and conditions. Understanding the underlying physiological and neurological processes that take place during stress and meditation techniques may be critical for effectively ...
Barnes, Vernon A., Crawford, Molly W., Ravinder, Jerath   +2 more
core  

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Socio-demographic differentiation of selected risk factors in a group of patients with respiratory system diseases

Studia Medyczne, 2017
Introduction : Tobacco smoking is the major risk factor of respiratory system diseases. However, it is worth noticing other crucial factors increasing the risk of such diseases, such as alcohol consumption, obesity, excess fat tissue around the neck and ...
Agnieszka B. Bartoszek, Katarzyna H. Kocka, Justyna Dejneka, Barbara Ślusarska, Marcin Rząca   +4 more
doaj   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Advances in Diagnostics and Management of Respiratory System Diseases

Diagnostics, 2023
Recently, significant innovations in the diagnosis and management of respiratory diseases have been developed [...]
Paola Confalonieri, Francesco Salton, Marco Confalonieri, Riccardo Pozzan, Barbara Ruaro   +4 more
openaire   +3 more sources

National mortality burden due to communicable, non-communicable, and other diseases in Ethiopia, 1990–2015: findings from the Global Burden of Disease Study 2015 [PDF]

, 2017
Background: Ethiopia lacks a complete vital registration system that would assist in measuring disease burden and risk factors. We used the Global Burden of Diseases, Injuries, and Risk factors 2015 (GBD 2015) estimates to describe the mortality burden ...
A Misganaw, A Misganaw, Amare Deribew, AR Omran, Awoke Misganaw, Azmeraw T. Amare, B Weldearegawi, Biruck Desalegn Yirsaw, Central Statistical Agency (CSA) [Ethiopia] and ICF, CJL Murray, D Chandramohan, D Hailemariam, D Shamebo, D Shamebo, F Tesfaye, F Tesfaye, Federal Ministry of Health, Ethiopia, GA Biks, GBD 2013 Mortality and Causes of Death Collaborators, Gizachew Assefa Tessema, H Wang, Jed Blore, K Lulu, Kebede Deribe, Kristopher J. Krohn, L Chaker, M Naghavi, Mesoud Mohammed, MH Forouzanfar, Mohsen Naghavi, Molla Gedefaw, Muluken Dessalegn, NJ Kassebaum, P Byass, S Accorsi, S Kuruvilla, Semaw Ferede Abera, Solomon Abrha Damtew, T Araya, Tilahun N. Haregu, Tolesa Bekele, Tom Achoki, W Deressa, Yibeltal Assefa, Yihunie Lakew, Yohannes Adama Melaku   +45 more
core   +2 more sources

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Elderly Nutrition Problems. [PDF]

, 2014
In old age people suffer from internal organs diseases very often. More than 90% of the elderly have these diseases. As much as one third of all older people complain of cardiovascular, respiratory and digestive diseases, diseases of the ...
Кравченко, В. С.
core  

Concentrations of Cysteinyl Leukotrienes in Various Biological Fluids of Children with Bronchial Asthma, Atopic Dermatitis and Food Protein Induced Enterocolitis [PDF]

, 2019
Clinical manifestation of food allergy is characterized by polymorphic cutaneous, respiratory and gastrointestinal syndromes. Leukotrienes occupy a key place in the pathogenesis of a wide range of inflammatory diseases, including bronchial asthma ...
Haiduchyk, H. (Halyna), Shadrin, O. (Oleg)   +1 more
core   +3 more sources