Results 61 to 70 of about 181,687,172 (282)

Quantifying age-related rates of social contact using diaries in a rural coastal population of Kenya [PDF]

, 2014
Background Improved understanding and quantification of social contact patterns that govern the transmission dynamics of respiratory viral infections has utility in the design of preventative and control measures such as vaccination and social ...
Medley, Graham Francis, Dorothy Chelagat Koech, David James Nokes, Moses Chapa Kiti (615990), Timothy Muiruri Kinyanjui (615991), Dorothy Chelagat Koech (615992), Koech, Dorothy Chelagat, Nokes, D. James, Nokes, David James, Patrick Kiio Munywoki, Kinyanjui, Timothy Muiruri, Moses Chapa Kiti, Timothy Muiruri Kinyanjui, Kiti, Moses Chapa, Munywoki, Patrick Kiio, Graham Francis Medley, Patrick Kiio Munywoki (615993), Graham Francis Medley (615994), Medley, Graham, Kinyanjui, Timothy, David James Nokes (615995)   +20 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Incidence and risk factors for respiratory syncytial virus and human metapneumovirus infections among children in the remote highlands of Peru [PDF]

, 2015
The disease burden and risk factors for respiratory syncytial virus (RSV) and human metapneumovirus (MPV) infections among children living in remote, rural areas remain unclear.; We conducted a prospective, household-based cohort study of children aged ...
Gil, Ana I., Philip J Budge, Kathryn M. Edwards (534416), Verastegui, Hector, Yuwei Zhu, Hector Verastegui, Grijalva, Carlos G, Carlos G. Grijalva, Grijalva, Carlos G., Stella Hartinger, Stella Hartinger (759804), Gil, Ana I, Marie R Griffin, Griffin, Marie R., Wu, Andrew, Lanata, Claudio F., Marie R. Griffin (209725), Marie R. Griffin, Monika Johnson, Ana I. Gil, Philip J. Budge (389401), Williams, John, Andrew Wu, Carlos G. Grijalva (236548), John Williams (32544), Zhu, Yuwei, Claudio F Lanata, Hector Verastegui (534417), Kathryn M Edwards, Andrew Wu (90389), Edwards, Kathryn M, John Williams, Yuwei Zhu (236550), Budge, Philip J, Johnson, Monika, Hartinger, Stella, Ana I. Gil (534420), Lanata, Claudio F, Ana I Gil, Claudio F. Lanata, Edwards, Kathryn M., Philip J. Budge, Griffin, Marie R, Carlos G Grijalva, Andrew Wu, Kathryn M. Edwards, Claudio F. Lanata (454212), Monika Johnson (12861), Budge, Philip J.   +48 more
core   +2 more sources

The respiratory neuromuscular system in Pompe disease [PDF]

Respiratory Physiology & Neurobiology, 2013
Pompe disease is due to mutations in the gene encoding the lysosomal enzyme acid α-glucosidase (GAA). Absence of functional GAA typically results in cardiorespiratory failure in the first year; reduced GAA activity is associated with progressive respiratory failure later in life.
David D, Fuller, Mai K, ElMallah, Barbara K, Smith, Manuela, Corti, Lee Ann, Lawson, Darin J, Falk, Barry J, Byrne   +6 more
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Comparison of contact patterns relevant for transmission of respiratory pathogens in Thailand and the Netherlands using respondent-driven sampling [PDF]

, 2014
Understanding infection dynamics of respiratory diseases requires the identification and quantification of behavioural, social and environmental factors that permit the transmission of these infections between humans.
Bengtsson, Linus, Mathuros Tipayamongkholgul, Linus Bengtsson, van Steenbergen, Jim E., Jim E. van Steenbergen (507103), Anna E. Thorson, Mart L Stein, Methodology and statistics for the behavioural and social sciences, Linus Bengtsson (121931), Jim E van Steenbergen, Peter G. M. van der Heijden (507107), Xin Lu, Social Networks, Solidarity and Inequality, Thorson, Anna E., Mart L. Stein, Chanyasanha, Charnchudhi, Mirjam E. E. Kretzschmar (392050), Buskens, Vincent, Leerstoel Heijden, Kretzschmar, Mirjam E E, Vincent Buskens, Jim E. van Steenbergen, Peter G M van der Heijden, Peter G. M. van der Heijden, Xin Lu (24821), Vincent Buskens (507106), Stein, Mart L., Van Der Heijden, Peter G M, Anna E. Thorson (507109), Mathuros Tipayamongkholgul (507105), Charnchudhi Chanyasanha, Anna E Thorson, Leerstoel Buskens, Mirjam E E Kretzschmar, Mart L. Stein (3283890), Kretzschmar, Mirjam E.E., Charnchudhi Chanyasanha (507104), Lu, Xin, Mirjam E. E. Kretzschmar, van der Heijden, Peter G.M., Tipayamongkholgul, Mathuros   +40 more
core   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

New causative agents of respiratory tract diseases in immunocompromized patients (a review)

Наука и инновации в медицине, 2019
The diseases of the respiratory system occupy one of the leading positions in the range of morbidities among the Russian population, both in adults and children.
Danir D. Ismatullin, Maksim O. Zolotov, Artem V. Lyamin, Tatyana R. Nikitina, Elena A. Zheleznova, Aleksandr V. Zhestkov   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source