Results 161 to 170 of about 15,596 (270)

Polygenic Risk Score Combined with Transcranial Sonography Refines Parkinson's Disease Risk Prediction

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Dopaminergic neuron depletion in the substantia nigra (SN) and the pathological aggregation of α‐synuclein are the neuropathological hallmarks of Parkinson's disease (PD). Objectives This study aimed to investigate the association between the polygenic risk score for PD (PD‐PRS) and transcranial sonography (TCS)‐measured SN ...
Mart Kals   +11 more
wiley   +1 more source

Magnetic Resonance–Guided Focused Ultrasound Treatment for Essential Tremor: A Single‐Center Experience

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Essential tremor is the most common hyperkinetic movement disorder. Magnetic resonance imaging–guided focused ultrasound (MRgFUS) has emerged as second‐line therapy. Objective The aim was to obtain the results of the first 108 patients treated with MRgFUS in Denmark.
Victor S. Hvingelby   +31 more
wiley   +1 more source

Role of the Functional Gait Assessment in Validating Item Difficulty Hierarchy and Fall Risk for Idiopathic Normal Pressure Hydrocephalus

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Falls along with gait‐balance disturbances are important symptoms of idiopathic normal pressure hydrocephalus (iNPH). Objectives This study aimed to validate the Functional Gait Assessment (FGA) item‐difficulty hierarchy, determine its optimal fall cutoff value, and identify key items for assessing fall risk in iNPH.
Yasutaka Nikaido   +8 more
wiley   +1 more source

DrugtargetMR, an Integrated Software for Identifying Genetic Determinants Underlying Human Complex Traits

open access: yesMed Research, EarlyView.
The DrugtargetMR integrates multiple models and methods through a comprehensive workflow that includes data preparation, core analysis, and visualization to identify disease‐associated susceptibility loci and genes, corresponding to the inner, middle, and outer circles, respectively.
Qiong Lyu   +3 more
wiley   +1 more source

Associations Between Lipids and Lipid‐Lowering Drug Target Genes and Osteomyelitis: A Mendelian Randomization Analysis

open access: yesMedicine Advances, EarlyView.
In this study, we identified several SNPs in PCSK9 as genetic tools to comprehensively assess the influential role of PCSK9 in CHD, CRP, and osteomyelitis. PCSK9 is associated with a lower risk of osteomyelitis, and PCSK9 is also associated with a reduction in CRP concentrations. Our study supports the notion that WC may be a potential mediator between
Zhiyi Zhou   +8 more
wiley   +1 more source

Population genomic analyses reveal extensive genomic regions within selective sweeps associated with adaptation and demographic history of a wheat fungal pathogen

open access: yesNew Plant Protection, EarlyView.
Applying population genomics, this study revealed that Pst exhibits slower linkage disequilibrium decay compared to rust fungi with known sexual reproduction, identified extensive hard and soft sweeps linked to Pst adaptation, and demonstrated that crop domestication and breeding programs have significantly influenced pathogen population sizes ...
Yun Xing   +14 more
wiley   +1 more source

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