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Assortative Mating and Linkage Disequilibrium [PDF]

G3: Genes, Genomes, Genetics, 2017
Assortative mating has been suggested to result in an increase in heritability and additive genetic variance through an increase in linkage disequilibrium.
Philip W. Hedrick
doaj   +7 more sources

Volume measures for linkage disequilibrium [PDF]

BMC Genetics, 2006
Background Defining measures of linkage disequilibrium (LD) that have good small sample properties and are applicable to multiallelic markers poses some challenges. The potential of volume measures in this context has been noted before, but their use has
Lin Chia-Ho, Chen Yuguo, Sabatti Chiara
doaj   +5 more sources

GPU-accelerated linkage disequilibrium scans reveal non-independent assortment of human non-homologous chromosomes [PDF]

Genome Biology
Background The independence of assortment between loci on non‑homologous chromosomes, as proposed by Mendel’s laws, has not been rigorously validated at the whole‑genome scale due to the computational demands of estimating inter‑chromosomal linkage ...
Wenhua Lv, Yuping Zou, Zhenwei Shang, Siyu Wei, Chen Sun, Jing Xu, Haiyan Chen, Junxian Tao, Hongsheng Tian, Shuo Bi, Xuying Guo, Yu Dong, Chen Zhang, Mingming Zhang, Hongchao Lv, Yongshuai Jiang   +15 more
doaj   +2 more sources

Linkage disequilibrium in wild mice. [PDF]

PLoS Genetics, 2007
Crosses between laboratory strains of mice provide a powerful way of detecting quantitative trait loci for complex traits related to human disease. Hundreds of these loci have been detected, but only a small number of the underlying causative genes have ...
Cathy C Laurie, Deborah A Nickerson, Amy D Anderson, Bruce S Weir, Robert J Livingston, Matthew D Dean, Kimberly L Smith, Eric E Schadt, Michael W Nachman   +8 more
doaj   +4 more sources

Structural variants in linkage disequilibrium with GWAS-significant SNPs [PDF]

Heliyon
With the recent expansion of structural variant identification in the human genome, understanding the role of these impactful variants in disease architecture is critically important.
Hao Liang, Joni C. Sedillo, Steven J. Schrodi, Akihiro Ikeda   +3 more
doaj   +2 more sources

Linkage Disequilibrium Decay in Selected Cattle Breeds [PDF]

Animals
Linkage disequilibrium (LD) maps are fundamental tools for exploring the genetic basis of traits of interest in any species. Quantifying LD patterns in cattle breeds has been made possible due to the availability of huge quantities of SNPs through modern
Farhad Bordbar, Just Jensen, Armughan Ahmed Wadood, Zipei Yao   +3 more
doaj   +2 more sources

Incorporating additive genetic effects and linkage disequilibrium information to discover gene-environment interactions using BV-LDER-GE [PDF]

Genome Biology
Uncovering environmental factors interacting with genetic factors to influence complex traits is important in genetic epidemiology and disease etiology. We introduce BiVariate Linkage-Disequilibrium Eigenvalue Regression for Gene-Environment interactions
Zihan Dong, Wei Jiang, Jiangnan Shen, Hongyu Li, Yuhan Xie, Andrew T. DeWan, Hongyu Zhao   +6 more
doaj   +2 more sources

Linkage disequilibrium between rare mutations [PDF]

Genetics, 2022
Benjamin Good
exaly   +2 more sources

The Genetic Architecture of Juvenile Growth Traits in the Conifer Torreya grandis as Revealed by Joint Linkage and Linkage Disequilibrium Mapping

Frontiers in Plant Science, 2022
Despite its high economical and ornamental values, Torreya grandis, a dioecious non-timber coniferous species, has long been an underrepresented species.
Wenchong Chen, Weiwu Yu, Ang Dong, Yanru Zeng, Huwei Yuan, Bingsong Zheng, Rongling Wu, Rongling Wu   +7 more
doaj   +1 more source

THE DIRECTION OF LINKAGE DISEQUILIBRIUM [PDF]

Genetics, 1974
ABSTRACT The previous paper (LANGLEYT,O BARanId KOJIMA 1974) reports that the directional linkage disequilibria, Dw = PABPab-PAbPaB, tend to be negative for data between allozymes and linked to inversions. A and B stand for the two alleles with the greatest frequency in the population. In this paper we show that linkage disequilibrium in
C H, Langley, J F, Crow
openaire   +2 more sources