Results 21 to 30 of about 193,370 (286)

Plasmodium falciparum: linkage disequilibrium between loci in chromosomes 7 and 5 and chloroquine selective pressure in Northern Nigeria. [PDF]

, 2001
In view of the recent discovery (Molecular Cell 6, 861-871) of a (Lys76Thr) codon change in gene pfcrt on chromosome 7 which determines in vitro chloroquine resistance in Plasmodium falciparum, we have re-examined samples taken before treatment in our ...
Boko, Pelagie, Dadzie, Samuel, Djogbenou, Luc, Donnelly, Martin, Dowd, Andrew, Jenkins, Adam M., Lu, Fang, Mayans, Olga, Mitchell, Sara N., Muskavitch, Marc A. T., Paine, Mark, Ranson, Hilary, Regna, Kimberly, Rigden, Daniel J., Weetman, David, Wilding, Craig S.   +15 more
core   +7 more sources

MIDAS: software for analysis and visualisation of interallelic disequilibrium between multiallelic markers

BMC Bioinformatics, 2006
Background Various software tools are available for the display of pairwise linkage disequilibrium across multiple single nucleotide polymorphisms. The HapMap project also presents these graphics within their website.
Day Ian NM, Zapata Carlos, Rodriguez Santiago, Gaunt Tom R   +3 more
doaj   +1 more source

The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem [PDF]

, 2016
Several important and fundamental aspects of disease genetics models have yet to be described. One such property is the relationship of disease association statistics at a marker site closely linked to a disease causing site.
Bansal, Naveen K., Farazi, Manzur R., He, Max M., Hebbring, Scott J., Li, Xiang, Maadooliat, Mehdi, Schrodi, Steven J., Upadhya, Jibal, Ye, Zhan   +8 more
core   +3 more sources

Whole genome linkage disequilibrium maps in cattle

BMC Genetics, 2007
Background Bovine whole genome linkage disequilibrium maps were constructed for eight breeds of cattle. These data provide fundamental information concerning bovine genome organization which will allow the design of studies to associate genetic variation
Mannen Hideyuki, Gao Chuan, Gill Clare A, Neto Emmanuel, Crews Denny, Coppieters Wouter, Aerts Jan, Matukumalli Lakshmi K, Murdoch Brenda M, Schnabel Robert D, McKay Stephanie D, Stothard Paul, Wang Zhiquan, Van Tassell Curt P, Williams John L, Taylor Jeremy F, Moore Stephen S   +16 more
doaj   +1 more source

Genome resequencing reveals multiscale geographic structure and extensive linkage disequilibrium in the forest tree Populus trichocarpa [PDF]

, 2009
This is the publisher’s final pdf. The article is copyrighted by the New Phytologist Trust and published by John Wiley & Sons, Inc. It can be found at: http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291469-8137.
Slavov, Gancho Trifonu, Difazio, Stephen P., Martin, Joel, Schackwitz, Wendy, Muchero, Wellington, Rodgers-Melnick, Eli, Lipphardt, Mindie F., Pennacchio, Christa P., Hellsten, Uffe, Pennacchio, Len A., Gunter, Lee E., Ranjan, Priya, Vining, Kelly, Pomraning, Kyle R., Wilhelm, Larry J., Pellegrini, Matteo, Mockler, Todd C., Freitag, Michael, Geraldes, Armando, El-Kassaby, Yousry A., Mansfield, Shawn D., Cronk, Quentin C. B., Douglas, Carl J., Strauss, Steven H., Rokhsar, Dan, Tuskan, Gerald A.   +25 more
core   +4 more sources

A linkage disequilibrium-based approach to selecting disease-associated rare variants.

PLoS ONE, 2013
Rare variants have increasingly been cited as major contributors in the disease etiology of several complex disorders. Recently, several approaches have been proposed for analyzing the association of rare variants with disease.
Rajesh Talluri, Sanjay Shete
doaj   +1 more source

Bayesian estimates of linkage disequilibrium

BMC Genetics, 2007
Background The maximum likelihood estimator of D' – a standard measure of linkage disequilibrium – is biased toward disequilibrium, and the bias is particularly evident in small samples and rare haplotypes.
Abad-Grau María M, Sebastiani Paola
doaj   +1 more source

A rapid method of haplotyping HFE mutations and linkage disequilibrium in a Caucasoid population [PDF]

, 1998
Background—HFE mutations are associated with hereditary haemochromatosis. However, a simple method capable of demonstrating the cis/transarrangement of alleles is lacking, and linkage disequilibrium betweenHFE alleles and classic HLA loci is unknown ...
Mullighan, C.G., Bunce, M., Fanning, G.C., Marshall, S.E., Welsh, K.I.   +4 more
core   +2 more sources

Robust Tests in Genome-Wide Scans under Incomplete Linkage Disequilibrium [PDF]

, 2009
Under complete linkage disequilibrium (LD), robust tests often have greater power than Pearson's chi-square test and trend tests for the analysis of case-control genetic association studies.
Geller, Nancy, Joo, Jungnam, Wu, Colin, Zaykin, Dmitri, Zheng, Gang   +4 more
core   +1 more source

Linkage disequilibrium fine mapping of quantitative trait loci: A simulation study

Genetics Selection Evolution, 2003
Recently, the use of linkage disequilibrium (LD) to locate genes which affect quantitative traits (QTL) has received an increasing interest, but the plausibility of fine mapping using linkage disequilibrium techniques for QTL has not been well studied ...
Pérez-Enciso Miguel, Cierco-Ayrolles Christine, Goffinet Bruno, Abdallah Jihad M   +3 more
doaj   +1 more source