Results 11 to 20 of about 127,775 (292)

Assortative Mating and Linkage Disequilibrium [PDF]

G3: Genes, Genomes, Genetics, 2017
Assortative mating has been suggested to result in an increase in heritability and additive genetic variance through an increase in linkage disequilibrium.
Philip W. Hedrick
doaj   +7 more sources

Whole genome linkage disequilibrium maps in cattle [PDF]

BMC Genetics, 2007
Background Bovine whole genome linkage disequilibrium maps were constructed for eight breeds of cattle. These data provide fundamental information concerning bovine genome organization which will allow the design of studies to associate genetic variation
Mannen Hideyuki, Gao Chuan, Gill Clare A, Neto Emmanuel, Crews Denny, Coppieters Wouter, Aerts Jan, Matukumalli Lakshmi K, Murdoch Brenda M, Schnabel Robert D, McKay Stephanie D, Stothard Paul, Wang Zhiquan, Van Tassell Curt P, Williams John L, Taylor Jeremy F, Moore Stephen S   +16 more
doaj   +4 more sources

Volume measures for linkage disequilibrium [PDF]

BMC Genetics, 2006
Background Defining measures of linkage disequilibrium (LD) that have good small sample properties and are applicable to multiallelic markers poses some challenges. The potential of volume measures in this context has been noted before, but their use has
Lin Chia-Ho, Chen Yuguo, Sabatti Chiara
doaj   +5 more sources

GPU-accelerated linkage disequilibrium scans reveal non-independent assortment of human non-homologous chromosomes [PDF]

Genome Biology
Background The independence of assortment between loci on non‑homologous chromosomes, as proposed by Mendel’s laws, has not been rigorously validated at the whole‑genome scale due to the computational demands of estimating inter‑chromosomal linkage ...
Wenhua Lv, Yuping Zou, Zhenwei Shang, Siyu Wei, Chen Sun, Jing Xu, Haiyan Chen, Junxian Tao, Hongsheng Tian, Shuo Bi, Xuying Guo, Yu Dong, Chen Zhang, Mingming Zhang, Hongchao Lv, Yongshuai Jiang   +15 more
doaj   +2 more sources

Linkage disequilibrium in wild mice. [PDF]

PLoS Genetics, 2007
Crosses between laboratory strains of mice provide a powerful way of detecting quantitative trait loci for complex traits related to human disease. Hundreds of these loci have been detected, but only a small number of the underlying causative genes have ...
Cathy C Laurie, Deborah A Nickerson, Amy D Anderson, Bruce S Weir, Robert J Livingston, Matthew D Dean, Kimberly L Smith, Eric E Schadt, Michael W Nachman   +8 more
doaj   +4 more sources

Optimal linkage disequilibrium splitting. [PDF]

Bioinformatics, 2021
Abstract Motivation A few algorithms have been developed for splitting the genome in nearly independent blocks of linkage disequilibrium. Due to the complexity of this problem, these algorithms rely on heuristics, which makes them suboptimal.
Privé F.
europepmc   +6 more sources

Cosmopolitan linkage disequilibrium maps [PDF]

Human Genomics, 2005
Linkage maps have been invaluable for the positional cloning of many genes involved in severe human diseases. Standard genetic linkage maps have been constructed for this purpose from the Centre d'Etude du Polymorphisme Humain and other panels, and have ...
Gibson Jane, Tapper William, Zhang Weihua, Morton Newton, Collins Andrew   +4 more
doaj   +4 more sources

Structural variants in linkage disequilibrium with GWAS-significant SNPs [PDF]

Heliyon
With the recent expansion of structural variant identification in the human genome, understanding the role of these impactful variants in disease architecture is critically important.
Hao Liang, Joni C. Sedillo, Steven J. Schrodi, Akihiro Ikeda   +3 more
doaj   +2 more sources

Bayesian estimates of linkage disequilibrium [PDF]

BMC Genetics, 2007
Background The maximum likelihood estimator of D' – a standard measure of linkage disequilibrium – is biased toward disequilibrium, and the bias is particularly evident in small samples and rare haplotypes.
Abad-Grau María M, Sebastiani Paola
doaj   +5 more sources

Linkage Disequilibrium Decay in Selected Cattle Breeds [PDF]

Animals
Linkage disequilibrium (LD) maps are fundamental tools for exploring the genetic basis of traits of interest in any species. Quantifying LD patterns in cattle breeds has been made possible due to the availability of huge quantities of SNPs through modern
Farhad Bordbar, Just Jensen, Armughan Ahmed Wadood, Zipei Yao   +3 more
doaj   +2 more sources