Results 171 to 180 of about 290,563 (234)

<i>AKT1</i> but not <i>AKT2</i> single nucleotide polymorphisms are associated with the risk of microscopic polyangiitis. [PDF]

PeerJ
Li L, Tan H, Peng Y, Chu L, Yang J, Tang W, Tan K, Fu S, Huang M, Xu M, Rao J, Xue C, Chen Y.   +12 more
europepmc   +1 more source

Circulating Rhythmic Metabolites and Causal Risk of Type 2 Diabetes in Adults in the Canadian Longitudinal Study on Aging

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Circadian regulation of metabolism is an important factor in metabolic health, yet the role of rhythmic metabolites in Type 2 diabetes development remains poorly understood. This study investigated associations between circulating rhythmic metabolites and incident Type 2 diabetes risk and evaluated causal relationships using two‐sample ...
Divya Joshi, Talha Rafiq, Marie Pigeyre, Renee de Mutsert, Femke Rutters, David J.T. Campbell, Jean‐Pierre Despres, Andre C. Carpentier, Joris Hoeks, Patrick Schrauwen, Parminder Raina   +10 more
wiley   +1 more source

Exploring the shared genetic architecture between periodontitis and cardiovascular disease. [PDF]

BDJ Open
Jin T, Lin J, Zhang P, Lu Y, Chen S, Lin H.   +5 more
europepmc   +1 more source

Proteomic Profiling of Plasma to Uncover Novel Intervention Targets and Prognostic Biomarkers for Chronic Liver Diseases

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The burden of chronic liver disease (CLD) is increasing. This study aims to identify protein markers for CLD and its progression, and develop a protein‐based risk prediction model. Materials and Methods We used proteome‐wide Mendelian randomization (MR), Bayesian colocalization and summary‐data‐based MR with proteomic data from deCODE ...
Xinxuan Li, Jing Sun, Jianhui Zhao, Fangyuan Jiang, Meng Zhang, Hao Wu, Shuai Yuan, Xue Li, Juan Lu, Christos S. Mantzoros   +9 more
wiley   +1 more source

A Lack of Complete Linkage Disequilibrium Between c.1236G>A and c.1129-5923C>G HapB3 Variants of <i>DPYD</i>: A Call to Revise European Pharmacogenetic Guidelines. [PDF]

Int J Mol Sci
Gil-Rodriguez A, Recarey-Rama S, Fernández Montes A, Rodríguez-Viyuela A, Barros F, Carracedo A, Maroñas O.   +6 more
europepmc   +1 more source

Lagged climate‐driven range shifts at species' leading, but not trailing, range edges revealed by multispecies seed addition experiment

Ecography, EarlyView.
Climate change is causing many species' ranges to shift upslope to higher elevations as species track their climatic requirements. However, many species have not shifted in pace with recent warming (i.e. ‘range stasis'), possibly due to demographic lags or microclimatic buffering.
Katie J. A. Goodwin, Nathalie I. Chardon, Kavya Pradhan, Janneke Hille Ris Lambers, Amy L. Angert   +4 more
wiley   +1 more source

The Potential Role of Haploblocks in the Persistence of Small, Isolated Populations of Brook Trout (<i>Salvelinus fontinalis</i>). [PDF]

Ecol Evol
Nemeczek CM, Delgado ML, Smith ME, MacMillan J, Van Wyngaarden M, Ruzzante DE.   +5 more
europepmc   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

Refractory Status Epilepticus as an Initial Manifestation of IgA Nephropathy. [PDF]

J Clin Neurol
Kwack DW, Hwang H, Park JY, Kim DW.
europepmc   +1 more source