Results 191 to 200 of about 308,435 (331)

Disequilibrium Chemistry

open access: yes, 2016
Oral presentation given at the ExoClimes 2016, held on August 1-4th, 2016 at Quest University (Squamish, Canada).
openaire   +1 more source

Mendelian Randomization Analysis of the Causal Link Between Rheumatoid Arthritis and Interstitial Lung Disease

open access: yesRespirology, EarlyView.
This Mendelian randomization study provides genetic evidence supporting a causal effect of rheumatoid arthritis on the risk of interstitial lung disease, highlighting potential shared mechanisms between autoimmune arthritis and pulmonary fibrosis. ABSTRACT Background and Objectives Rheumatoid arthritis (RA) is a systemic autoimmune disease that is ...
Mengyu Zhang   +5 more
wiley   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

open access: yesVIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai   +11 more
wiley   +1 more source

A Lack of Complete Linkage Disequilibrium Between c.1236G>A and c.1129-5923C>G HapB3 Variants of <i>DPYD</i>: A Call to Revise European Pharmacogenetic Guidelines. [PDF]

open access: yesInt J Mol Sci
Gil-Rodriguez A   +6 more
europepmc   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou   +4 more
wiley   +1 more source

Sex Hormones and the Risk of Nasal Polyps: A Two‐Sample Mendelian Randomization Study

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective The pathophysiological roles of sex hormones in airway inflammation have drawn much attention recently. We aimed to explore the causal effect of sex hormones on chronic rhinosinusitis (CRS) and nasal polyps (NP) via a Mendelian randomization (MR) study.
Ying Zhu   +7 more
wiley   +1 more source

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