Results 201 to 210 of about 15,596 (270)
Multi‐ancestry genome‐wide association study of topiramate's effects on heavy alcohol use
Alcohol, Clinical and Experimental Research, Volume 49, Issue 6, Page 1197-1205, June 2025.Topiramate reduces alcohol consumption, but genetic predictors of treatment response have not been identified. We conducted a GWAS in 8386 individuals from the Million Veteran Program, evaluating genetic variants associated with the change in alcohol consumption before and after initiating topiramate.
Christal N. Davis +4 more
wiley +1 more source
Genetic structure and the search for genotype-phenotype relationships: an example from disequilibrium in the Apo B gene region. [PDF]
, 1991 Kim E. Zerba +3 more
openalex +1 more source
Animal Conservation, EarlyView.We developed a set of innovative landscape resistance models to identify how climatic, topographic and vegetation variables influenced gene flow in the iconic Australian platypus across a 300 km2 urbanised landscape. Our research identified topographic wetness, rainfall and vegetation cover as consistently important for maintaining landscape‐scale gene
Tamielle Brunt, Annabel L. Smith
wiley +1 more source
Extensive linkage disequilibrium in the achaete-scute complex of Drosophila melanogaster. [PDF]
, 1990 J. Michael Macpherson +2 more
openalex +1 more source
Associations of plasma sex‐related hormone and protein levels and alcohol dependence
Addiction, EarlyView.Abstract Background and Aims Sex‐related hormones and proteins may underlie sex differences in alcohol use disorder characteristics and consequences. Previous reports suggest steroid sex hormones may influence alcohol consumption behaviors while proteins that regulate their circulation levels are rarely investigated.
Ada Man‐Choi Ho +6 more
wiley +1 more source
Methods for multiancestry genome‐wide association study meta‐analysis
Annals of Human Genetics, EarlyView.Abstract Genome‐wide association studies (GWAS) have significantly enhanced our understanding of the genetic basis of complex diseases. Despite the technological advancements, gaps in our understanding remain, partly due to small effect sizes and inadequate coverage of genetic variation.
Chuan Fu Yap, Andrew P. Morris
wiley +1 more source
The molecular basis of lactase persistence: Linking genetics and epigenetics
Annals of Human Genetics, EarlyView.Abstract Lactase persistence (LP) — the genetic trait that determines the continued expression of the enzyme lactase into adulthood — has undergone recent, rapid positive selection since the advent of animal domestication and dairying in some human populations.
Céleste E. Cohen +2 more
wiley +1 more source