Results 221 to 230 of about 174,103 (341)

Optimization and Evaluation of the bestRAD Sequencing Approach: Towards Ascertainment of the Invasion Routes of the Oriental Fruit Fly, Bactrocera dorsalis

open access: yesMolecular Ecology Resources, EarlyView.
ABSTRACT The bestRAD technique is a reduced genome representation approach with high‐capacity sample multiplexing and physical isolation of biotin‐labelled target DNA fragments using streptavidin beads, which should reduce total cost and genotyping errors. While we here formalise the relevance of this approach within the HTS landscape, our foremost aim
Emeline Charbonnel   +7 more
wiley   +1 more source

Benchmarking Imputed Low Coverage Genomes in a Human Population Genetics Context

open access: yesMolecular Ecology Resources, EarlyView.
ABSTRACT Ongoing advances in population genomic methodologies have recently enabled the study of millions of loci across hundreds of genomes at a relatively low cost, by leveraging a combination of low‐coverage shotgun sequencing and innovative genotype imputation methods.
Gludhug A. Purnomo   +4 more
wiley   +1 more source

‘Highly‐Informative’ Genetic Markers Can Bias Conclusions: Examples and General Solutions

open access: yesMolecular Ecology Resources, EarlyView.
ABSTRACT High‐grading bias is the overestimation power in a subset of loci caused by model overfitting. Using both empirical and simulated datasets, we show that high‐grading bias can cause severe overestimation of population structure, and thus mislead investigators, whenever highly informative or high‐FST markers are chosen (i.e., ascertained) and ...
Andy Lee   +4 more
wiley   +1 more source

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