Results 31 to 40 of about 479,852 (230)

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Discrete dislocation dynamics simulations of dislocation-$\theta'$ precipitate interaction in Al-Cu alloys

, 2018
The mechanisms of dislocation/precipitate interaction were studied by means of discrete dislocation dynamics within a multiscale approach. Simulations were carried out using the discrete continuous method in combination with a fast Fourier transform ...
Capolungo, L., Esteban-Manzanares, G., LLorca, J., Papadimitriou, I., Santos-Güemes, R., Segurado, J.   +5 more
core   +1 more source

FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes

FEBS Open Bio, EarlyView.
FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang, Wenhui Yu, Cui Dang, Jingjing Zhang, Jiahan Lu, Jing Xue   +5 more
wiley   +1 more source

Micro-plasticity and intermittent dislocation activity in a simplified micro structural model

, 2013
Here we present a model to study the micro-plastic regime of a stress-strain curve. In this model an explicit dislocation population represents the mobile dislocation content and an internal shear-stress field represents a mean-field description of the ...
, Abramowitz M, Argon A S, Bulatov V V, Devincre B, Hull D, Ispánovity P D, Kuhlmann-Wilsdorf D, Lebyodkin M A, Nabarro F R N, Neuhäuser H, P M Derlet, R Maaß, Van der Giessen E, Weygand D   +14 more
core   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

An elastoplastic theory of dislocations as a physical field theory with torsion

, 2002
We consider a static theory of dislocations with moment stress in an anisotropic or isotropic elastoplastical material as a T(3)-gauge theory. We obtain Yang-Mills type field equations which express the force and the moment equilibrium.
Abrikosov A A, Barut A O, Bilby B A, Cartan É, Edelen D G B, Edelen D G B, Eringen A C, Eshelby J D, Eshelby J D, Frankel T, Gairola B K D, Gairola B K D, Golebiewska-Lasota A A, Gronwald F, Gutkin M Yu, Hamermesh M, Hehl F W, Hehl F W, Hirth J P, Kadic A, Katanaev M O, Kondo K, Kosevich A M, Kröner E, Kröner E, Kröner E, Kröner E, Kröner E, Kröner E, Kröner E, Kröner E, Kröner E, Marsden J E, Maugin G A, Nabarro F R N, Nye J F, Peierls R E, Puntigam R A, Rogula D, Schaefer H, Seeger A, Trautman A, Trautman A, Trebin H-R, Trzesowski A   +44 more
core   +1 more source

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

Aging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

Stability of Elastic Glass Phases in Random Field XY Magnets and Vortex Lattices in Type II Superconductors

, 1996
A description of a dislocation-free elastic glass phase in terms of domain walls is developed and used as the basis of a renormalization group analysis of the energetics of dislocation loops added to the system.
A. I. Larkin, D. S. Fisher, D. S. Fisher, D. S. Fisher, Daniel S. Fisher, G. Blatter, J. Kierfeld, J. Villain, M. Aizenman, M. C. Marchetti, M. J. P. Gingras, T. Giamarchi, T. Hwa, T. Natterman, Y. Imry   +14 more
core   +1 more source

Probing microplasticity in small scale FCC crystals via Dynamic Mechanical Analysis [PDF]

, 2016
In small-scale metallic systems, collective dislocation activity has been correlated with size effects in strength and with a step-like plastic response under uniaxial compression and tension.
Adhikari, Rana X, Greer, Julia R., Ni, Xiaoyue, Papanikolaou, Stefanos, Vajente, Gabriele   +4 more
core   +5 more sources

Toward a human‐centric co‐design methodology for AI detection of differences between planned and delivered dose in radiotherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction Many artificial intelligence (AI) solutions have been proposed to enhance the radiotherapy (RT) workflow, but limited applications have been implemented to date, suggesting an implementation gap. One contributing factor to this gap is a misalignment between AI systems and their users.
Luca M. Heising, Frank Verhaegen, Stefan G. Scheib, Maria J. G. Jacobs, Carol X. J. Ou, Viola Mottarella, Yin‐Ho Chong, Mariangela Zamburlini, Sebastiaan M. J. J. G. Nijsten, Ans Swinnen, Michel Öllers, Cecile J. A. Wolfs   +11 more
wiley   +1 more source