Results 31 to 40 of about 17,381 (265)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Functional and Practical Taxonomy for the Industrial Implementation of Highly Automated Reverse Manufacturing Cells

IEEE Open Journal of the Industrial Electronics Society
While it is a widespread understanding that the sustainability of the global economy requires a transition to a circular economy paradigm where a growing share of the raw materials resources used for the manufacturing of the products are recycled when ...
Annagiulia Morachioli, Vladimir Sivtsov, Nicolas Rojas, Fabio Bonsignorio   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Approach For Optimized Dismantling Strategies And Design For Recycling Of Electric Traction Drives

Proceedings of the Conference on Production Systems and Logistics
With the widespread adoption of electric vehicles (EVs), there arises a pressing need for sustainable processing of electric traction drives (ETDs) at the end of their life cycles.
Hahn, Roman, Wieprecht, Nico, Ihne, Thorsten, Kühl, Alexander, Franke, Jörg   +4 more
doaj   +1 more source

Upscaling of Permanent Magnet Dismantling and Recycling through VALOMAG Project

Materials Proceedings, 2021
Neodymium-Iron-Boron (NdFeB) based permanent magnets are indispensable in today’s technology-driven society. Moreover, their use is likely to increase since they are key in clean energy applications such as wind turbines, hybrid/electric vehicles, and ...
Fernando Coelho, Shoshan Abrahami, Yongxiang Yang, Benjamin Sprecher, Zhijie Li, Nour-Eddine Menad, Kathy Bru, Thibaut Marcon, Cyril Rado, Boris Saje, Marie-Lise Sablayrolles, Virginie Decottignies   +11 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Decommissioning of the ASTRA research reactor: Dismantling of the biological shield [PDF]

Nuclear Technology and Radiation Protection, 2006
The paper describes the dismantling of the inactive and activated areas of the biological shield of the ASTRA research reactor at the Austrian Research Center in Seibersdorf. The calculation of the parameters determining the activated areas at the shield
Meyer Franz, Steger Ferdinand
doaj   +1 more source

Tailored Hierarchical Porous Copper Architectures via Three Dimensional Printing and Pressure‐less Sintering for Next‐Generation Lithium‐Metal Batteries

Advanced Engineering Materials, EarlyView.
A hierarchical porous copper current collector is fabricated via three‐dimensional printing combined with pressureless sintering to stabilize lithium metal anodes. The interconnected architecture lowers local current density, guides uniform Li deposition within pores, and suppresses dendrite growth.
Alok Kumar Mishra, Mukul Shukla
wiley   +1 more source